USP26 is a peptidase enzyme. The USP26 gene is an X-linked gene exclusively expressed in the testis and it codes for the ubiquitin-specific protease 26.[1] The USP26 gene is found at Xq26.2 on the X-chromosome as a single exon. The enzyme that this gene encodes comprises 913 amino acid residues and it is 104 kilodalton in size, which is transcribed from a sequence of 2794 nucleotide base-pairs on the X-chromosome.[2] The USP26 enzyme is a deubiquitinating enzyme that places a very significant role in the regulation of protein turnover during spermatogenesis. It is a testis-specific enzyme that is solely express in spermatogonia and can prevent the degradation of ubiquitinated USP26 substrates.[3]
| ubiquitin specific peptidase 26 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | USP26 | ||||||
| NCBI gene | 83844 | ||||||
| HGNC | 13485 | ||||||
| OMIM | 300309 | ||||||
| RefSeq | NM_031907 | ||||||
| UniProt | Q9BXU7 | ||||||
| Other data | |||||||
| EC number | 3.1.2.15 | ||||||
| Locus | Chr. X q26.2 | ||||||
| |||||||
Recent research has suggested that defects in USP26 may be involved in some cases of male infertility,[1][4] specifically Sertoli cell-only syndrome, and an absence of sperm in the ejaculate (azoospermia).[5]
See also
editReferences
edit- ^ a b Stouffs K, Lissens W, Tournaye H, Van Steirteghem A, Liebaers I (March 2005). "Possible role of USP26 in patients with severely impaired spermatogenesis". European Journal of Human Genetics. 13 (3): 336–40. doi:10.1038/sj.ejhg.5201335. PMID 15562280.
- ^ Liu YL, Zheng J, Mi YJ, Zhao J, Tian QB (January 2018). "The impacts of nineteen mutations on the enzymatic activity of USP26". Gene. 641: 292–296. doi:10.1016/j.gene.2017.10.074. PMID 29111204.
- ^ Lahav-Baratz, Shirly; Kravtsova-Ivantsiv, Yelena; Golan, Shay; Ciechanover, Aaron (January 2017). "The testis-specific USP26 is a deubiquitinating enzyme of the ubiquitin ligase Mdm2". Biochemical and Biophysical Research Communications. 482 (1): 106–111. doi:10.1016/j.bbrc.2016.10.135. ISSN 0006-291X. PMID 27810359.
- ^ Zhang J, Qiu SD, Li SB, Zhou DX, Tian H, Huo YW, Ge L, Zhang QY (November 2007). "Novel mutations in ubiquitin-specific protease 26 gene might cause spermatogenesis impairment and male infertility". Asian Journal of Andrology. 9 (6): 809–14. doi:10.1111/j.1745-7262.2007.00305.x. PMID 17968467.
- ^ Ravel C, El Houate B, Chantot S, Lourenço D, Dumaine A, Rouba H, Bandyopadahyay A, Radhakrishna U, Das B, Sengupta S, Mandelbaum J, Siffroi JP, McElreavey K (October 2006). "Haplotypes, mutations and male fertility: the story of the testis-specific ubiquitin protease USP26". Molecular Human Reproduction. 12 (10): 643–6. doi:10.1093/molehr/gal063. PMID 16888075.
External links
edit- USP26+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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