USP34

Ubiquitin carboxyl-terminal hydrolase 34 is an enzyme that in humans is encoded by the USP34 gene.

USP34
Identifiers
Aliases	USP34, ubiquitin specific peptidase 34
External IDs	OMIM: 615295; MGI: 109473; HomoloGene: 40978; GeneCards: USP34; OMA:USP34 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2p15 Start 61,187,463 bp End 61,471,087 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 A3.2|11 14.29 cM Start 23,256,895 bp End 23,440,560 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nipple renal medulla cardia pylorus ventral tegmental area trigeminal ganglion superior surface of tongue inferior ganglion of vagus nerve external globus pallidus sperm Top expressed in superior cervical ganglion conjunctival fornix barrel cortex primary oocyte genital tubercle vas deferens tail of embryo CA3 field spermatocyte substantia nigra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding cysteine-type endopeptidase activity cysteine-type peptidase activity peptidase activity hydrolase activity thiol-dependent deubiquitinase Cellular component cytosol Biological process proteolysis ubiquitin-dependent protein catabolic process positive regulation of canonical Wnt signaling pathway protein K48-linked deubiquitination Wnt signaling pathway protein deubiquitination regulation of protein stability Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9736 17847 Ensembl ENSG00000115464 ENSMUSG00000056342 UniProt Q70CQ2 Q6ZQ93 RefSeq (mRNA) NM_014709 NM_001190401 RefSeq (protein) NP_055524 NP_001177330 Location (UCSC) Chr 2: 61.19 – 61.47 Mb Chr 11: 23.26 – 23.44 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Quesada V, Díaz-Perales A, Gutiérrez-Fernández A, et al. (2004). "Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases". Biochem. Biophys. Res. Commun. 314 (1): 54–62. doi:10.1016/j.bbrc.2003.12.050. PMID 14715245.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.