USP36

Ubiquitin-specific protease 36 is an enzyme that in humans is encoded by the USP36 gene.

USP36
Identifiers
Aliases	USP36, DUB1, ubiquitin specific peptidase 36
External IDs	OMIM: 612543; MGI: 1919594; HomoloGene: 11828; GeneCards: USP36; OMA:USP36 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q25.3 Start 78,787,381 bp End 78,841,441 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 E2 Start 118,150,477 bp End 118,181,070 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve anterior pituitary left ovary right ovary left uterine tube body of pancreas right hemisphere of cerebellum skin of leg skin of abdomen gastric mucosa Top expressed in Rostral migratory stream zygote genital tubercle primitive streak neural layer of retina tail of embryo lacrimal gland muscle of thigh epiblast otic vesicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function thiol-dependent deubiquitinase peptidase activity cysteine-type peptidase activity hydrolase activity RNA binding Cellular component nucleolus nucleus nuclear speck Biological process protein deubiquitination regulation of autophagy of mitochondrion ubiquitin-dependent protein catabolic process positive regulation of protein targeting to mitochondrion proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57602 72344 Ensembl ENSG00000055483 ENSMUSG00000033909 UniProt Q9P275 B1AQJ2 RefSeq (mRNA) NM_025090 NM_001321291 NM_001033528 RefSeq (protein) NP_001308220 NP_001028700 Location (UCSC) Chr 17: 78.79 – 78.84 Mb Chr 11: 118.15 – 118.18 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the ubiquitin-specific protease family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the nucleoli and deubiquitinate nucleophosmin and fibrillarin

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–150. doi:10.1093/dnares/7.2.143. PMID 10819331.
• Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–4109. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Quesada V, Díaz-Perales A, Gutiérrez-Fernández A, et al. (2004). "Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases". Biochem. Biophys. Res. Commun. 314 (1): 54–62. doi:10.1016/j.bbrc.2003.12.050. PMID 14715245.
• Kim MS, Yoo KJ, Kang I, et al. (2005). "A novel cysteine protease HeLa DUB-1 responsible for cleaving the ubiquitin in human ovarian cancer cells". Int. J. Oncol. 25 (2): 373–9. doi:10.3892/ijo.25.2.373. PMID 15254734.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Kim MS, Kim YK, Kim YS, et al. (2005). "Deubiquitinating enzyme USP36 contains the PEST motif and is polyubiquitinated". Biochem. Biophys. Res. Commun. 330 (3): 797–804. doi:10.1016/j.bbrc.2005.03.051. PMID 15809067.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–5396. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.