USP37

Ubiquitin specific processing protease 37 is an enzyme that in humans, is encoded by the USP37 gene.

USP37
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3U12
Identifiers
Aliases	USP37, ubiquitin specific peptidase 37
External IDs	MGI: 2442483; HomoloGene: 10858; GeneCards: USP37; OMA:USP37 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q35 Start 218,450,251 bp End 218,568,351 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 C3- C4 Start 74,474,670 bp End 74,583,443 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte Achilles tendon sperm testicle gonad epithelium of colon corpus callosum thymus skin of arm Skeletal muscle tissue of rectus abdominis Top expressed in spermatocyte spermatid hand zygote secondary oocyte otolith organ utricle tail of embryo primary oocyte genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity cysteine-type endopeptidase activity cysteine-type peptidase activity protein binding protein kinase binding hydrolase activity thiol-dependent deubiquitinase Cellular component nucleus nucleoplasm Biological process cell cycle protein K48-linked deubiquitination ubiquitin-dependent protein catabolic process protein K11-linked deubiquitination proteolysis cell division regulation of DNA replication protein deubiquitination G1/S transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57695 319651 Ensembl ENSG00000135913 ENSMUSG00000033364 UniProt Q86T82 Q8C0R0 RefSeq (mRNA) NM_020935 NM_176972 NM_001310662 RefSeq (protein) NP_065986 NP_001297591 NP_795946 Location (UCSC) Chr 2: 218.45 – 218.57 Mb Chr 1: 74.47 – 74.58 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Quesada V, Díaz-Perales A, Gutiérrez-Fernández A, et al. (2004). "Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases". Biochem. Biophys. Res. Commun. 314 (1): 54–62. doi:10.1016/j.bbrc.2003.12.050. PMID 14715245.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.