USP39

U4/U6.U5 tri-snRNP-associated protein 2 is a protein that in humans is encoded by the USP39 gene.

USP39
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3JCR
Identifiers
Aliases	USP39, 65K, HSPC332, SAD1, SNRNP65, CGI-21, ubiquitin specific peptidase 39
External IDs	OMIM: 611594; MGI: 107622; HomoloGene: 13183; GeneCards: USP39; OMA:USP39 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2p11.2 Start 85,602,856 bp End 85,649,283 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6 C1|6 32.27 cM Start 72,295,661 bp End 72,322,167 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence gastrocnemius muscle granulocyte muscle of thigh monocyte stromal cell of endometrium muscle layer of sigmoid colon upper lobe of left lung right lung Top expressed in epiblast ventricular zone tail of embryo spermatocyte placenta yolk sac granulocyte ganglionic eminence genital tubercle bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function thiol-dependent deubiquitinase zinc ion binding metal ion binding protein binding Cellular component spliceosomal complex nucleus nucleoplasm U4/U6 x U5 tri-snRNP complex Biological process protein deubiquitination mRNA splicing, via spliceosome cell cycle mRNA processing RNA splicing cell division spliceosomal complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10713 28035 Ensembl ENSG00000168883 ENSMUSG00000056305 UniProt Q53GS9 Q3TIX9 RefSeq (mRNA) NM_001256725 NM_001256726 NM_001256727 NM_001256728 NM_006590 NM_138592 RefSeq (protein) NP_001243654 NP_001243655 NP_001243656 NP_001243657 NP_006581 NP_613058 Location (UCSC) Chr 2: 85.6 – 85.65 Mb Chr 6: 72.3 – 72.32 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Lygerou Z, Christophides G, Séraphin B (1999). "A novel genetic screen for snRNP assembly factors in yeast identifies a conserved protein, Sad1p, also required for pre-mRNA splicing". Mol. Cell. Biol. 19 (3): 2008–20. doi:10.1128/mcb.19.3.2008. PMC 83994. PMID 10022888.
• Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–713. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
• Makarova OV, Makarov EM, Lührmann R (2001). "The 65 and 110 kDa SR-related proteins of the U4/U6.U5 tri-snRNP are essential for the assembly of mature spliceosomes". EMBO J. 20 (10): 2553–2563. doi:10.1093/emboj/20.10.2553. PMC 125249. PMID 11350945.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.