USS Leyden has been the name of more than one United States Navy ship, and may refer to:
- USS Leyden (1865), an armed tug in commission from 1866 to 1903
- USS Leyden (IX-167), a naval auxiliary in commission from 1944 to 1945
This article includes a list of ships with the same or similar names. If an internal link for a specific ship led you here, you may wish to change the link to point directly to the intended ship article, if one exists.