USS Osprey has been the name of various United States Navy ships, and may refer to:

  • USS Osprey (AM-29), a minesweeper in commission from 1919 to 1920
  • USS Osprey (AM-56), a minesweeper commissioned in 1940 and sunk in 1944
  • USS Osprey (AM-406), a minesweeper cancelled in 1945
  • USS Osprey (AMS-28), originally USS YMS–422, a minesweeper commissioned in 1944, renamed Osprey in 1947, and transferred to the Japanese Maritime Self Defense Force in 1955
  • USS Osprey (MHC-51), a coastal minehunter in commission from 1993 to 2006

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