USS Otsego may refer to the following ships of the United States Navy:
- USS Otsego (1840), was a small schooner obtained on loan from the Army in 1840 for action against the Seminole Indians
- USS Otsego (1863), was a gunboat commissioned in the spring of 1864
- USS Tunxis (1864) was a light draft monitor originally which was renamed Hydra in 1869 and Ostego? later that year
- SS Otsego was a passenger-cargo steamship built in Germany in 1902 as Prinz Eitel Friedrich which in 1919 served as the troop transport USS Otsego (ID-1628)
This article includes a list of ships with the same or similar names. If an internal link for a specific ship led you here, you may wish to change the link to point directly to the intended ship article, if one exists.