USS Safeguard is a name used more than once by the United States Navy:
- USS Safeguard (ARS-25), laid down, 5 June 1943, at Basalt Rock Co. Inc., Napa, California.
- USNS Safeguard (T-ARS-50), laid down on 8 November 1982 by Peterson Builders, Sturgeon Bay, Wisconsin; launched on 12 November 1983; and commissioned on 17 August 1985.
This article includes a list of ships with the same or similar names. If an internal link for a specific ship led you here, you may wish to change the link to point directly to the intended ship article, if one exists.