USS Sproston was the name of two destroyers of the United States Navy. Both ships were named for Lieutenant John G. Sproston, an officer of the US Navy during the American Civil War.
- USS Sproston (DD-173), a Wickes-class destroyer in service from 1919 to 1922
- USS Sproston (DD-577), a Fletcher-class destroyer in service from 1943 to 1968
This article includes a list of ships with the same or similar names. If an internal link for a specific ship led you here, you may wish to change the link to point directly to the intended ship article, if one exists.