Ubiquitin conjugating enzyme e2 q2

Ubiquitin conjugating enzyme E2 Q2 is a protein that in humans is encoded by the UBE2Q2 gene.

UBE2Q2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZUO
Identifiers
Aliases	UBE2Q2, ubiquitin conjugating enzyme E2 Q2
External IDs	OMIM: 612501; MGI: 2388672; HomoloGene: 45455; GeneCards: UBE2Q2; OMA:UBE2Q2 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q24.2 Start 75,843,307 bp End 75,901,078 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 B Start 55,056,138 bp End 55,114,813 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte tibia palpebral conjunctiva Achilles tendon parietal pleura visceral pleura synovial membrane synovial joint germinal epithelium saphenous vein Top expressed in superior cervical ganglion spermatid seminal vesicula interventricular septum parotid gland spermatocyte hand muscle of thigh visual cortex right kidney More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding ATP binding ubiquitin-protein transferase activity ubiquitin conjugating enzyme activity Cellular component cytoplasm cytosol Biological process protein K48-linked ubiquitination protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 92912 109161 Ensembl ENSG00000140367 ENSMUSG00000032307 UniProt Q8WVN8 Q8K2Z8 RefSeq (mRNA) NM_001145335 NM_001284382 NM_173469 NM_180600 NM_001346657 NM_001346658 RefSeq (protein) NP_001138807 NP_001271311 NP_775740 NP_001333586 NP_001333587 NP_850931 Location (UCSC) Chr 15: 75.84 – 75.9 Mb Chr 9: 55.06 – 55.11 Mb PubMed search
Wikidata
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Further reading

• Seghatoleslam A, Zambrano A, Millon R, Ganguli G, Argentini M, Cromer A, Abecassis J, Wasylyk B (2006). "Analysis of a novel human gene, LOC92912, over-expressed in hypopharyngeal tumours". Biochem. Biophys. Res. Commun. 339 (1): 422–9. doi:10.1016/j.bbrc.2005.11.026. PMID 16300736.
• Banerjee S, Brooks WS, Crawford DF (2007). "Inactivation of the ubiquitin conjugating enzyme UBE2Q2 causes a prophase arrest and enhanced apoptosis in response to microtubule inhibiting agents". Oncogene. 26 (45): 6509–17. doi:10.1038/sj.onc.1210471. PMID 17471241.
• Maeda H, Miyajima N, Kano S, Tsukiyama T, Okumura F, Fukuda S, Hatakeyama S (2009). "Ubiquitin-conjugating enzyme UBE2Q2 suppresses cell proliferation and is down-regulated in recurrent head and neck cancer". Mol. Cancer Res. 7 (9): 1553–62. doi:10.1158/1541-7786.MCR-08-0543. PMID 19723876.
• Nikseresht M, Seghatoleslam A, Monabati A, Talei A, Ghalati FB, Owji AA (2010). "Overexpression of the novel human gene, UBE2Q2, in breast cancer". Cancer Genet. Cytogenet. 197 (2): 101–6. doi:10.1016/j.cancergencyto.2009.11.020. PMID 20193842.
• Köttgen A, Pattaro C, Böger CA, Fuchsberger C, Olden M, Glazer NL, Parsa A, Gao X, Yang Q, Smith AV, O'Connell JR, Li M, Schmidt H, Tanaka T, Isaacs A, Ketkar S, Hwang SJ, Johnson AD, Dehghan A, Teumer A, Paré G, Atkinson EJ, Zeller T, Lohman K, Cornelis MC, Probst-Hensch NM, Kronenberg F, Tönjes A, Hayward C, Aspelund T, Eiriksdottir G, Launer LJ, Harris TB, Rampersaud E, Mitchell BD, Arking DE, Boerwinkle E, Struchalin M, Cavalieri M, Singleton A, Giallauria F, Metter J, de Boer IH, Haritunians T, Lumley T, Siscovick D, Psaty BM, Zillikens MC, Oostra BA, Feitosa M, Province M, de Andrade M, Turner ST, Schillert A, Ziegler A, Wild PS, Schnabel RB, Wilde S, Munzel TF, Leak TS, Illig T, Klopp N, Meisinger C, Wichmann HE, Koenig W, Zgaga L, Zemunik T, Kolcic I, Minelli C, Hu FB, Johansson A, Igl W, Zaboli G, Wild SH, Wright AF, Campbell H, Ellinghaus D, Schreiber S, Aulchenko YS, Felix JF, Rivadeneira F, Uitterlinden AG, Hofman A, Imboden M, Nitsch D, Brandstätter A, Kollerits B, Kedenko L, Mägi R, Stumvoll M, Kovacs P, Boban M, Campbell S, Endlich K, Völzke H, Kroemer HK, Nauck M, Völker U, Polasek O, Vitart V, Badola S, Parker AN, Ridker PM, Kardia SL, Blankenberg S, Liu Y, Curhan GC, Franke A, Rochat T, Paulweber B, Prokopenko I, Wang W, Gudnason V, Shuldiner AR, Coresh J, Schmidt R, Ferrucci L, Shlipak MG, van Duijn CM, Borecki I, Krämer BK, Rudan I, Gyllensten U, Wilson JF, Witteman JC, Pramstaller PP, Rettig R, Hastie N, Chasman DI, Kao WH, Heid IM, Fox CS (2010). "New loci associated with kidney function and chronic kidney disease". Nat. Genet. 42 (5): 376–84. doi:10.1038/ng.568. PMC 2997674. PMID 20383146.
• Seghatoleslam A, Monabati A, Bozorg-Ghalati F, Nikseresht M, Bordbar MR, Rahvar M, Owji AA (2012). "Expression of UBE2Q2, a putative member of the ubiquitin-conjugating enzyme family in pediatric acute lymphoblastic leukemia". Arch Iran Med. 15 (6): 352–5. PMID 22642244.