Uglješa (Serbian: Угљеша) is a Serbian masculine given name. It may refer to:
- Uglješa Kojadinović (1936–1982), actor
- Uglješa Mrnjavčević (1346–1371), medieval nobleman
- Uglješa Radinović (born 1993), footballer
- Uglješa Šajtinac (born 1971), writer
- Uglješa Vlatković, medieval nobleman