Wikipedia

Ulrich Schwaneberg

Ulrich Schwaneberg (born 17 June 1969 in Waiblingen, Germany) is a German chemist and protein engineer. He is the Chair of Biotechnology[1] at RWTH Aachen University and member of the scientific board [2] at the Leibniz Institute for Interactive Materials in Aachen. He specializes in directed evolution of proteins for material science applications and on the development of its methodologies. The latter comprise methods for diversity generation (e.g. PLICing,[3] SeSaM,[4] OmniChange,[5] cepPCR,[6] PePevo[7]), as well as high-throughput screening systems (e.g. Fur-Shell).[8] His work group has elucidated general design principles of enzymes by analyzing libraries that contain the full natural diversity of a hydrolase with single amino acid exchanges and developed strategies to efficiently explore the protein sequence space (e.g. KnowVolution)[9] and discovered protein engineering principles.

Ulrich Schwaneberg
Born (1969-06-17) 17 June 1969 (age 55)
Waiblingen
NationalityGerman
CitizenshipGerman
Alma materUniversity of Stuttgart
Scientific career
FieldsProtein Engineering
InstitutionsRWTH Aachen University
Websitewww.biotec.rwth-aachen.de/go/id/imne/

Career

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Ulrich Schwaneberg studied chemistry at the University of Stuttgart and received his diploma in 1996. His doctoral studies were also conducted at University of Stuttgart in the Institute of Technical Biochemistry under the supervision of R. D. Schmid. After his graduation in July 1999, he joined the lab of Frances H. Arnold at California Institute of Technology as post-doctoral fellow for two years. In January 2002, he was appointed as professor at Jacobs University Bremen. In January 2009, he was appointed as head of the Institute of Biotechnology at RWTH Aachen University and in 2010 co-appointed to the scientific board of directors at the DWI Leibniz Institute for Interactive Materials. Furthermore, he serves on the board of directors in the Bioeconomy Science Center that aims at advancing and focussing research efforts in the area of bioeconomy in the state of North Rhine-Westphalia and serves as speaker of the industry lab HICAST (Henkel Innovation Campus for Advanced and Sustainable Technologies) at RWTH Aachen University[10]

He is a co-inventor on a number of patents of several improved enzymes which have been transferred into industrial use. In 2008, he also co-founded the SeSaM-Biotech GmbH which offers directed evolution services[11] In 2013, he received a visiting professorship for senior international scientists of the Chinese Academy of Science, in 2015 a specially appointed professorship at Osaka University, in 2016 the 1.7 M € BMBF award for the Next Generation of Biotechnological Processes and in 2018 the Innovation Award of the BioRegions in Germany for a plant health release technology.[12]

References

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  1. ^ Biology, Department of. "Prof. Schwaneberg – RWTH AACHEN UNIVERSITY Department of Biology – English". www.biologie.rwth-aachen.de. Retrieved 8 June 2018.
  2. ^ "Scientific Board – Team – DWI – Leibniz Institute for Interactive Materials". www.dwi.rwth-aachen.de. Retrieved 8 June 2018.
  3. ^ Blanusa, Milan; Schenk, Alexander; Sadeghi, Hengameh; Marienhagen, Jan; Schwaneberg, Ulrich (2010). "Phosphorothioate-based ligase-independent gene cloning (PLICing): An enzyme-free and sequence-independent cloning method". Analytical Biochemistry. 406 (2). Elsevier BV: 141–146. doi:10.1016/j.ab.2010.07.011. ISSN 0003-2697. PMID 20646988.
  4. ^ Wong, T. S. (13 February 2004). "Sequence saturation mutagenesis (SeSaM): a novel method for directed evolution". Nucleic Acids Research. 32 (3). Oxford University Press (OUP): 26e–26. doi:10.1093/nar/gnh028. ISSN 1362-4962. PMC 373423. PMID 14872057.
  5. ^ Dennig, Alexander; Shivange, Amol V.; Marienhagen, Jan; Schwaneberg, Ulrich (19 October 2011). Marinus, Martin G. (ed.). "OmniChange: The Sequence Independent Method for Simultaneous Site-Saturation of Five Codons". PLOS ONE. 6 (10). Public Library of Science (PLoS): e26222. Bibcode:2011PLoSO...626222D. doi:10.1371/journal.pone.0026222. ISSN 1932-6203. PMC 3198389. PMID 22039444.
  6. ^ Yang, Jianhua; Ruff, Anna J.; Arlt, Marcus; Schwaneberg, Ulrich (23 May 2017). "Casting epPCR (cepPCR): A simple random mutagenesis method to generate high quality mutant libraries". Biotechnology and Bioengineering. 114 (9). Wiley: 1921–1927. doi:10.1002/bit.26327. ISSN 0006-3592. PMID 28464223. S2CID 5149806.
  7. ^ Rübsam, Kristin; Davari, Mehdi; Jakob, Felix; Schwaneberg, Ulrich (10 April 2018). "KnowVolution of the Polymer-Binding Peptide LCI for Improved Polypropylene Binding". Polymers. 10 (4). MDPI AG: 423. doi:10.3390/polym10040423. ISSN 2073-4360. PMC 6415234. PMID 30966458.
  8. ^ Körfer, Georgette; Pitzler, Christian; Vojcic, Ljubica; Martinez, Ronny; Schwaneberg, Ulrich (17 May 2016). "In vitro flow cytometry-based screening platform for cellulase engineering". Scientific Reports. 6 (1). Springer Science and Business Media LLC: 26128. Bibcode:2016NatSR...626128K. doi:10.1038/srep26128. ISSN 2045-2322. PMC 4869107. PMID 27184298.
  9. ^ Cheng, Feng; Zhu, Leilei; Schwaneberg, Ulrich (2015). "Directed evolution 2.0: improving and deciphering enzyme properties" (PDF). Chemical Communications. 51 (48). Royal Society of Chemistry (RSC): 9760–9772. doi:10.1039/c5cc01594d. ISSN 1359-7345. PMID 25874672.
  10. ^ "HICAST – Excellence for sustainable technologies – Bio-based News – The portal for bio-based economy & industrial biotechnology". bio-based.eu. 22 May 2015. Retrieved 8 June 2018.
  11. ^ "Where we come from – SeSaM-Biotech". sesam-biotech.com. Retrieved 8 June 2018.
  12. ^ "Innovationspreis der BioRegionen in Deutschland 2018 – Wir fördern Ihre innovative Idee!". www.innovationspreis-der-bioregionen.de (in German). Retrieved 8 June 2018.
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