Uracil/thymine dehydrogenase

Uracil/thymine dehydrogenase (EC 1.17.99.4, uracil oxidase, uracil-thymine oxidase, uracil dehydrogenase) is an enzyme with systematic name uracil:acceptor oxidoreductase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

Uracil/thymine dehydrogenase
Identifiers
EC no.1.17.99.4
CAS no.9029-00-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
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PDB structuresRCSB PDB PDBe PDBsum
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NCBIproteins
(1) uracil + H2O + acceptor barbiturate + reduced acceptor
(2) thymine + H2O + acceptor 5-methylbarbiturate + reduced acceptor

Uracil/thymine dehydrogenase forms part of the oxidative pyrimidine-degrading pathway in some microorganisms.

References

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  1. ^ Hayaishi O, Kornberg A (May 1952). "Metabolism of cytosine, thymine, uracil, and barbituric acid by bacterial enzymes". The Journal of Biological Chemistry. 197 (2): 717–32. PMID 12981104.
  2. ^ Wang TP, Lampen JO (February 1952). "Metabolism of pyrimidines by a soil bacterium". The Journal of Biological Chemistry. 194 (2): 775–83. PMID 14927671.
  3. ^ Wang TP, Lampen JO (February 1952). "Uracil oxidase and the isolation of barbituric acid from uracil oxidation". The Journal of Biological Chemistry. 194 (2): 785–91. PMID 14927672.
  4. ^ Lara FJ (August 1952). "On the decomposition of pyrimidines by bacteria. II. Studies with cell-free enzyme preparations". Journal of Bacteriology. 64 (2): 279–85. PMC 169350. PMID 14955523.
  5. ^ Soong CL, Ogawa J, Shimizu S (August 2001). "Novel amidohydrolytic reactions in oxidative pyrimidine metabolism: analysis of the barbiturase reaction and discovery of a novel enzyme, ureidomalonase". Biochemical and Biophysical Research Communications. 286 (1): 222–6. doi:10.1006/bbrc.2001.5356. PMID 11485332.
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