Uracilylalanine synthase

In enzymology, an uracilylalanine synthase (EC 2.5.1.53) is an enzyme that catalyzes the chemical reaction

uracilylalanine synthase
Identifiers
EC no.2.5.1.53
CAS no.113573-73-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins
O3-acetyl-L-serine + uracil 3-(uracil-1-yl)-L-alanine + acetate

Thus, the two substrates of this enzyme are O3-acetyl-L-serine and uracil, whereas its two products are 3-(uracil-1-yl)-L-alanine and acetate.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is O3-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase. Other names in common use include O3-acetyl-L-serine acetate-lyase (adding uracil), isowillardiine synthase, willardiine synthase, and 3-O-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase.

References

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  • Ahmmad MAS; Maskall CS; Brown EG (1984). "Partial-purification and properties of willardiine and synthase activity from Pisum sativum". Phytochemistry. 23 (2): 265–270. doi:10.1016/S0031-9422(00)80315-5.
  • Ikegami F, Kaneko M, Lambein F, Kuo, YH, Murakoshi I (1987). "Difference between uracilylalanine synthases and cysteine synthases in Pisum sativum". Phytochemistry. 26 (10): 2699–2704. doi:10.1016/S0031-9422(00)83575-X.
  • Kuo, YH; Lambein F (1978). "Biosynthesis of the uracilylalanines willardiine and isowillardiine in higher plants". Phytochemistry. 17 (9): 1571–1576. doi:10.1016/S0031-9422(00)94645-4.