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Ure2p is a yeast protein that represses transcription of genes involved in nitrogen catabolism. It specifically regulates the utilization of poor nitrogen sources in the presence of preferred nutrients such as ammonia or glutamine. Ure2p is one of the few yeast proteins that are known to be prions. At low frequency the protein adopts an alternative conformation that is auto-catalytic and self-propagating. Yeast cells that carry the protein in the prion conformation are designated as [URE3]. [1] Autocatalytic conversion of Ure2p into the inactive prion form of the protein results in a loss of repression of nitrogen catabolic genes.
| Transcriptional regulator URE2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | URE2 | ||||||
| Entrez | 855492 | ||||||
| HomoloGene | 22221 | ||||||
| RefSeq (mRNA) | NM_001183067.1 | ||||||
| RefSeq (Prot) | NP_014170.1 | ||||||
| UniProt | P23202 | ||||||
| Other data | |||||||
| Chromosome | XIV: 0.22 - 0.22 Mb | ||||||
| |||||||
References
edit- ^ Moriyama, Hiromitsu; Edskes, Herman K.; Wickner, Reed B. (2000-12-01). "[URE3] Prion Propagation in Saccharomyces cerevisiae: Requirement for Chaperone Hsp104 and Curing by Overexpressed Chaperone Ydj1p". Molecular and Cellular Biology. 20 (23). Informa UK Limited: 8916–8922. doi:10.1128/mcb.20.23.8916-8922.2000. ISSN 1098-5549. PMC 86546.
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