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In enzymology, an uridine phosphorylase (EC 2.4.2.3) is an enzyme that catalyzes the chemical reaction
| uridine phosphorylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.4.2.3 | ||||||||
| CAS no. | 9030-22-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
- uridine + phosphate uracil + alpha-D-ribose 1-phosphate
Thus, the two substrates of this enzyme are uridine and phosphate, whereas its two products are uracil and alpha-D-ribose 1-phosphate.
This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is uridine:phosphate alpha-D-ribosyltransferase. Other names in common use include pyrimidine phosphorylase, UrdPase, UPH, and UPase. This enzyme participates in pyrimidine metabolism.
Structural studies
editAs of late 2007, 27 structures have been solved for this class of enzymes, with PDB accession codes 1K3F, 1LX7, 1RXC, 1RXS, 1RXU, 1RXY, 1RYZ, 1SJ9, 1SQ6, 1T0U, 1TGV, 1TGY, 1U1C, 1U1D, 1U1E, 1U1F, 1U1G, 1Y1Q, 1Y1R, 1Y1S, 1Y1T, 1ZL2, 2HN9, 2HRD, 2HSW, 2HWU, and 2I8A.
References
edit- CANELLAKIS ES (1957). "Pyrimidine metabolism. II. Enzymatic pathways of uracil anabolism". J. Biol. Chem. 227 (1): 329–38. doi:10.1016/S0021-9258(18)70818-1. PMID 13449076.
- PAEGE LM, SCHLENK F (1952). "Bacterial uracil riboside phosphorylase". Arch. Biochem. Biophys. 40 (1): 42–9. doi:10.1016/0003-9861(52)90071-4. PMID 12997187.
- Pontis H, Degerstedt G, Reichard P (1961). "Uridine and deoxyuridine phosphorylases from Ehrlich ascites tumor". Biochim. Biophys. Acta. 51 (1): 138–147. doi:10.1016/0006-3002(61)91024-1. PMID 13737038.
