Group 6: Braun, Froehlich, Hasanin, Isaac

Topic: Two-Pore Channel

Secondary References:

  1. http://stke.sciencemag.org/content/8/384/re7
  2. https://www.ncbi.nlm.nih.gov/pubmed/26679949
  3. http://ajprenal.physiology.org/content/279/5/F793.full

Organization / Outline:

1. General information

2. Basic features

a. Type (voltage-gated)

b. Structure

c. Domains (TCP1, TCP2)

d. Localization (Acidic organelles)

3. Biological(/Physiological) Roles

a. Function

b. Dysfunction/Pathophysiology

i. Parkinson’s Disease

ii. Fatty Liver Disease

iii. Ebola

c. Membrane Trafficking

4. History/Discovery

5. References