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Andrew William Truman (born July 29, 1979) is a British-American Biochemist and Cancer Biologist [1]. He is an Associate Professor in Biological Sciences at the University of North Carolina at Charlotte and both a Senior Editor for the journal Cell Stress and Chaperones [2] and a Review Editor for Frontiers in Molecular Biosciences[3]. He became a fellow of the Cell Stress Society International (FSSI) in 2020.
Education
editDr. Truman attended high school at Wallington County Grammar School for Boys between 1990 and 1997. He received a B.Sc. (Hons) in Biochemistry in 2000 and a subsequent Ph.D. in Biochemistry in 2005 from University College London, UK.
Academic Career
editDr. Truman completed postdoctoral studies at Johns Hopkins Bloomberg School of Public Health and at Boston University. He joined the laboratory of Dr. Stephen Kron at the University of Chicago as a Research Professional Associate in 2010. In 2015, he joined the Department of Biological Sciences at UNC Charlotte as an Assistant Professor(https://www.trumanlab.org/) and in 2021 was promoted to Associate Professor with Tenure.
Research
editDr. Truman is recognized for his research on the interplay of molecular chaperones (especially Hsp70) and signal transduction pathways. In particular, he has been a major proponent of the idea of the Chaperone Code, the combination of post-translational modifications that regulate chaperone function. Truman’s laboratory has discovered a reliance of the important ribonucleotide reductase complex on molecular chaperones[4]. This work has led to other studies examining synergy between drugs that inhibit RNR and chaperones in cancer[5]. His research team is currently supported by grants from the National Institute of General Medical Sciences to explore the connection between chaperones and the cellular response to DNA damage[6].
Selected Publications
editFor the most current list of Truman lab papers, please see here
Nitika, Blackman, J.S., Knighton, L.E., Takakuwa, J.E., Calderwood, S.K. and Truman, A.W. (2020) Chemogenomic screening identifies the Hsp70 co-chaperone DNAJA1 as a hub for anticancer drug resistance. Sci Rep, 10, 13831.
Weissman, Z., Pinsky, M., Wolfgeher, D.J., Kron, S.J., Truman, A.W. and Kornitzer, D. (2020) Genetic analysis of Hsp70 phosphorylation sites reveals a role in Candida albicans cell and colony morphogenesis. Biochim Biophys Acta Proteins Proteom, 1868, 140135.
Rigo, M.M., Borges, T.J., Lang, B.J., Murshid, A., Nitika, Wolfgeher, D., Calderwood, S.K., Truman, A.W. and Bonorino, C. (2020) Host expression system modulates recombinant Hsp70 activity through post-translational modifications. FEBS J.
Nitika, Porter, C.M., Truman, A.W. and Truttmann, M.C. (2020) Post-translational modifications of Hsp70 family proteins: Expanding the chaperone code. J Biol Chem.
Xu, L., Nitika, Hasin, N., Cuskelly, D.D., Wolfgeher, D., Doyle, S., Moynagh, P., Perrett, S., Jones, G.W. and Truman, A.W. (2019) Rapid deacetylation of yeast Hsp70 mediates the cellular response to heat stress. Sci Rep, 9, 16260. [PDF]
Takakuwa, J.E., Nitika, Knighton, L.E. and Truman, A.W. (2019) Oligomerization of Hsp70: Current Perspectives on Regulation and Function. Front Mol Biosci, 6, 81.
Ricco, N., Flor, A., Wolfgeher, D., Efimova, E.V., Ramamurthy, A., Appelbe, O.K., Brinkman, J., Truman, A.W., Spiotto, M.T. and Kron, S.J. (2019) Mevalonate pathway activity as a determinant of radiation sensitivity in head and neck cancer. Mol Oncol, 13, 1927-1943.
Lotz, S.K., Knighton, L.E., Nitika, Jones, G.W. and Truman, A.W. (2019) Not quite the SSAme: unique roles for the yeast cytosolic Hsp70s. Curr Genet, 65, 1127-1134.
Knighton, L.E., Nitika, Waller, S.J., Strom, O., Wolfgeher, D., Reitzel, A.M. and Truman, A.W. (2019) Dynamic remodeling of the interactomes of Nematostella vectensis Hsp70 isoforms under heat shock. J Proteomics, 206, 103416.
Waller, S.J., Knighton, L.E., Crabtree, L.M., Perkins, A.L., Reitzel, A.M. and Truman, A.W. (2018) Characterizing functional differences in sea anemone Hsp70 isoforms using budding yeast. Cell Stress Chaperones, 23, 933-941.
Sluder, I.T., Nitika, Knighton, L.E. and Truman, A.W. (2018) The Hsp70 co-chaperone Ydj1/HDJ2 regulates ribonucleotide reductase activity. PLoS Genet, 14, e1007462.
Nitika and Truman, A.W. (2018) Endogenous epitope tagging of heat shock protein 70 isoform Hsc70 using CRISPR/Cas9. Cell Stress Chaperones, 23, 347-355.
Nitika and Truman, A.W. (2017) Cracking the Chaperone Code: Cellular Roles for Hsp70 Phosphorylation. Trends Biochem Sci, 42, 932-935.
Truman, A.W., Kristjansdottir, K., Wolfgeher, D., Ricco, N., Mayampurath, A., Volchenboum, S.L., Clotet, J. and Kron, S.J. (2015) Quantitative proteomics of the yeast Hsp70/Hsp90 interactomes during DNA damage reveal chaperone-dependent regulation of ribonucleotide reductase. J Proteomics, 112, 285-300.
Truman, A.W.K., A. A.; Fitz Gerald, J. N.; Kron, S. J. (2012) Cell Cycle: Regulation by Cyclins. eLS.
Truman, A.W., Kristjansdottir, K., Wolfgeher, D., Hasin, N., Polier, S., Zhang, H., Perrett, S., Prodromou, C., Jones, G.W. and Kron, S.J. (2012) CDK-dependent Hsp70 Phosphorylation controls G1 cyclin abundance and cell-cycle progression. Cell, 151, 1308-1318.
Truman, A.W., Kim, K.Y. and Levin, D.E. (2009) Mechanism of Mpk1 mitogen-activated protein kinase binding to the Swi4 transcription factor and its regulation by a novel caffeine-induced phosphorylation. Mol Cell Biol, 29, 6449-6461.