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Genetically variant organism (GVO) a novel noun for genome edited animals with short variations. Genome edited animals or plants are increasingly created for fundamental reearch or for various applications . They are often called genome edited organisms (GEOs). Two very different categories of GEO are created: organisms with permanent insertions of DNA and others with short deletions or punctal mutations. Organisms with permanent insertions of DNA introduced by genome editing are genetically modified organisms (GMO) bearing stretches of DNA which can be detected and tracked by PCR, propagated intentionnally or accidentally, and can potentially be harmful or detrimental, to human or its environment. Organisms with small mutations or deletions are genetically variant organisms (GVO). They bear mutations that can not make them be detrimental to the environment. They are very hard to track if the position of the mutation is not known. It is impossible to prove by which process they have obtained (involving for example genome editing by CRISPR-Cas9 or chemical mutagenesis). A majority of them are animal species reproducing mutations found in human causing diseases. Others are improved food. This dichotomic classification clarifies the debates on genome edited organisms by distinghuishing two very different categories of organisms that are not necessarily GMO.