B10 cells are a sub-class of regulatory B-cells (Breg cell) that are involved in inhibiting immune responses in both humans and mice.[1][2][3] B10 cells are named for their ability to produce inhibitory interleukin: Interleukin-10 (IL-10).[4][5] One of their unique abilities is that they suppress the innate and adaptive immune signals, making them important for regulating the inflammatory response. Like the B-cell, the B10 cell requires antigen specific binding to the surface of CD5 receptor to illicit a response from the T-cell. Once an antigen binds to the CD19 receptor, immediate downregulation in B-cell antigen receptor (BCR) signal expression occurs and mediates the release of IL-10 cytokines.[6]
History
editThe B10 cell was first characterized in 2008, as a different subset of B-cells in mice. By inducing hypersensitive T-cells the immune response of the mice were over reactive.[6] When compared to the wild type or normal expression of antigen receptors, the B-cells bound to CD19 molecules actually decreased inflammation. The in vivo model demonstrated that a new characterization of B-cell was producing IL-10 which was later defined as the B10 effector cells.
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- ^ Tedder, TF (15 February 2015). "B10 cells: a functionally defined regulatory B cell subset". Journal of Immunology. 194 (4): 1395–401. doi:10.4049/jimmunol.1401329. PMID 25663677. S2CID 207430556.
- ^ Candando, KM; Lykken, JM; Tedder, TF (May 2014). "B10 cell regulation of health and disease". Immunological Reviews. 259 (1): 259–72. doi:10.1111/imr.12176. PMC 4049540. PMID 24712471.
- ^ Lykken, JM; Candando, KM; Tedder, TF (October 2015). "Regulatory B10 cell development and function". International Immunology. 27 (10): 471–7. doi:10.1093/intimm/dxv046. PMC 4817073. PMID 26254185.
- ^ Mao, Y; Wang, Y; Dong, L; Zhang, Q; Wang, C; Zhang, Y; Li, X; Fu, Z (September 2019). "Circulating exosomes from esophageal squamous cell carcinoma mediate the generation of B10 and PD-1high Breg cells". Cancer Science. 110 (9): 2700–2710. doi:10.1111/cas.14122. PMC 6726703. PMID 31276257.
- ^ Liu, J; Chen, X; Hao, S; Zhao, H; Pang, L; Wang, L; Ren, H; Wang, C; Mao, H (15 October 2019). "Human chorionic gonadotropin and IL-35 contribute to the maintenance of peripheral immune tolerance during pregnancy through mediating the generation of IL-10+ or IL-35+ Breg cells". Experimental Cell Research. 383 (2): 111513. doi:10.1016/j.yexcr.2019.111513. PMID 31362000. S2CID 198998443.
- ^ a b Lykken, Jacquelyn M.; Candando, Kathleen M.; Tedder, Thomas F. (October 2015). "Regulatory B10 cell development and function". International Immunology. 27 (10): 471–477. doi:10.1093/intimm/dxv046. ISSN 0953-8178. PMC 4817073. PMID 26254185.