CraigClark

Backbone Chain Article Peer Review Edits by Monica P.:

• Add commas: "This science is subdivided into the study of organic polymers(,) which consist of a carbon backbone(,) and inorganic polymers(,) which have backbones containing only main group elements."
• Add comma: This backbone forms the primary sequence(,) thus directing folding and the nature of their complex structure.
• Lowercase categories: "The macromolecules within the body can be divided into four main subcategories, each of which are involved in very different and important biological processes: Proteins, Carbohydrates, Lipids, and Nucleic acids."
• Word changes: "Each of these molecules has a different backbone (chain) which is initially the driving factor of their different structure and function in the body."
• Sentence could be reformatted, link/ reword "moiety" "In a way the character of the backbone chain depends on the type of polymerization: in step-growth polymerization the monomer moiety becomes the backbone, and thus the backbone is typically functional, like in polythiophenes or low band gap polymers in organic semiconductors. "
• Spelled wrong: "e.g. in polisiloxanes the backbone chain is very flexible, resulting in very low glass transition temperature of -123 °C."
• Add however: "Carbohydrates have many roles in the body including functioning as, structural units, enzyme cofactors and cell surface recognition sites; however, their most prevalent role is as energy storage and delivery in cellular metabolic pathways."
• Add comma: "The bases stick out from the pentose-phosphate polymer backbone in DNA and are hydrogen bonded in pairs to their complementary partner (A with T and G with C) creating a double helix with pentose phosphate backbones on either side(,) thus forming a secondary structure"

Backbone Chain Article Peer Review Edits by Rayna T.:

• "This backbone forms the primary sequence(,) thus directing folding and the nature of their complex structure." It seems like this sentence could be reworded to be clearer. Who are you referring to by "their" in "their complex structure"? Were you referring to the backbone structure or the macromolecule as a whole? There are also a few misalignments in the text for plurality/singularity. For example, you used "their", which describes a group, with "complex structure", which is a singular characteristic.

• There is some repetition you could condense or remove to be more concise:
  • "The backbone is therefore directly related to biological molecules’ function" and "Each of these molecules has a different backbone which is initially the driving factor of their different structures and functions in the body" have similar meanings. You can combine the two ideas into one sentence.

• This is probably more of a stylistic choice, but it seems like there is some overlapping/repeated information talked about for the different macromolecules under the sections of "character of the backbone" and "overview of common backbones". For example, for proteins, you discussed the molecular makeup of the backbone as well as the different levels of structures in both sections. I think that if you weave your non-overlapping research about backbone characteristics for each major macromolecule into its respective section in "overview of common backbones", you could minimize repetition to have a more concise and straightforward article.
• "The character of the backbone, i.e. its flexibility, determines the thermal properties of the polymer (such as the glass transition temperature), e.g. in polisiloxanes the backbone chain is very flexible, resultin in very low glass transition temperature of -123 °C. The polymers with a rigid backbone are prone to crystallization (e.g. polythiophenes) in thin films and in solution." Since you provide more than one example, it could be better to have a break in the sentence between delivering the two examples. Also, are there multiple characters that can influence thermal properties? If so, the "i.e. flexibility" is valid, but you will need to change the sentence into plural form ("character" to "characters" and "determines" to "determine"). Perhaps you could also provide a brief definition including what an object's glass transition temperature is and what information it provides about a polymer's thermal properties so that readers can better understand its significance.
• "Crystallization in its turn affects the optical properties of the polymers, its optical band gap and electronic levels." I am not sure if you mean that the optical band gap and electronic levels are being listed with the optical properties of the polymers or if these characteristics are underneath the umbrella category of optical properties.
• I liked how you included pictures depicting the backbone chemistry you describe in each major macromolecules' overview section. The visual aids help to clarify steps of reactions and chemical groups that some readers may otherwise not be familiar with.
• I went in to tweak a bit of the wording and also fixed some minor grammatical errors.
• I enjoyed the amount of detail in this article! Nice work!

Backbone chain - this is very important to biological systems and biochemistry. It definitely has a lot of information that could be added and is commonly researched. I am very surprised the page is so sparse

Side chain - This is another very broad and very important topic that i am very surprised does not have a much longer and more complete Wikipedia page.

Cis-trans isomerase: I believe this is a wide and well studied topic in biochemistry yet the Wikipedia page is completely blank

Protein biosynthesis: This is a start rated page that is extremely underdeveloped. I also believe that it is very closely related to 153A

Are these topics too broad?