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4-Dehydroepiandrosterone is an adrenal steroid that is an isomer to 5-DHEA. The endogenous formation of androstenedione has been well documented in healthy human and animal tissues. Under DSHEA, 4-DHEA is a natural metabolite of androstenedione and DHEA that is proven to occur in rabbits, sheep and rats.(1,2) It is a pro-hormone to 4-androstenedione and 4-Androstenediol via 3bHSD and 17bHSD respectively.
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| Clinical data | |
|---|---|
| Other names | (3β)-3-Hydroxyandrost-4-en-17-one |
| Routes of administration | Oral |
| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Metabolism | Hepatic |
| Elimination half-life | 12 hours |
| Excretion | Urinary:?% |
| Chemical and physical data | |
| Formula | C19H28O2 |
| Molar mass | 288.424 g/mol g·mol−1 |
| 3D model (JSmol) | |
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Synonyms and brand names
editSynonyms for 4-dehydroepiandrosterone are:
3-beta-Hydroxy-4-androsten-17-one, 3.beta.-Hydroxyandrost-4-en-17-one, 3beta-hydroxy-4-androsten-17-one, 3beta-hydroxy-androst-4-en-17-one, 3beta-Hydroxy-D4-androsten-17-one, 3beta-Hydroxyandrost-4-en-17-one, 3beta-Hydroxyandrost-4-ene-17-one, 3-beta-hydroxy-etioallocholan-4-ene-17-one , 4-Androsten-3beta-ol-17-one,
References
edit1. BREUER H, DAHM K, NORYMBERSKI JK. ENZYMIC FORMATION OF 3-BETA-HYDROXYANDROST-4-EN-17-ONE. J Endocrinol. 1963 Nov;27:357-8.
2. THOMAS PZ, DORFMAN RI. METABOLISM OF ANDROST-4-ENE-3,17-DIONE-4-14C BY RABBIT SKELETAL MUSCLE SUPERNATANT FRACTION. ISOLATION OF 3BETA-HYDROXYANDROST-4-EN-17-ONE-14C AND TESTOSTERONE-14C. J Biol Chem. 1964 Mar;239:766-72.