Megatron is a character in the Transformers franchise with numerous incarnations. The name may refer to:
- Megatron, the leader of the Decepticons in The Transformers
- Megatron, the leader of the Predacons in Beast Wars and the leader of the Vehicons in Beast Machines
- Megatron, the leader of the Predacons and Decepticons in Transformers: Robots in Disguise
- Megatron, the leader of the Decepticons in Transformers: Armada, Energon, and Cybertron
- Megatron, the leader of the Decepticons in the Transformers film series
- Megatron, the leader of the Decepticons in Transformers Animated