Electrogrl72

My background: I'm an MD (internal medicine),with a masters in public health, and background in health services research. I'm a big believer in backing up statements with references, and also verifying that the references are based on sound scientific studies. I often use wikipedia as a starting point, and and have been pleased to see the quality of articles improve over the years. I'm here for the most part to add citations, and fill in small gaps. My areas of interest are generally medical or laboratory related, but whatever odd question my family or I come up with....we head off to the internet and don't rest until there's a definitive answer. If one exists.

In the interest of full disclosure, I'm currently employed with Helena Laboratories, a manufacturer of medical diagnostics. My intention is to provide factual data and citations. Please do not hesitate to point out to me any perception of bias.

Jessica Jones

Protein Electrophoresis

General information, interpretation, technology, agarose, capillary

Therapeutic monoclonal medications

Interference with SPE interpretion

Immunofixation electrophoresis

general information, interpretation, technology, agarose, capillary

Hemostatis

laboratory testing, interpretation, technology

lipids

lipoprotein(a): recent trials, meds in development.

thyromimetics

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993058/pdf/ukmss-32525.pdf I Tancevski et al. The resurgence of thyromimetics as lipid-modifying agents. Curr Opin Investig Drugs. 2009 September ; 10(9): 912–918

Eprotirome

thryomimetic cholesterol agent

Ladenson PW, et al. Use of the thyroid hormone analogue eprotirome in statin-treated dyslipidemia. N Engl J Med. 2010 Mar 11;362(10):906-16.

mechanism http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993058/?tool=pubmed Tancevski I. et al. The resurgence of thyromimetics as lipid-modifying agents. Curr Opin Investig Drugs. 2009 Sep;10(9):912-8.

2 small studies 1 single dose 24 patients placebo v med, total, LDL reduction, no adverse events multiple dose 24 patients placebo v med total, LDL reduction, no adverse events

http://www.pnas.org/content/105/2/663.full.pdf+html Berkenstam A. et al. The thyroid hormone mimetic compound KB2115 lowers plasma LDL cholesterol and stimulates bile acid synthesis without cardiac effects in humans. Anders Berkenstam PNAS January 15, 2008 vol. 105 no. 2 663-667.

Sobetirome

QuatRx Pharmaceuticals decreased LDL, LP(a) in mice PHASE I complete

Tancevski I. et al. Sobetirome: a selective thyromimetic for the treatment of dyslipidemia. Recent Pat Cardiovasc Drug Discov. 2011 Jan;6(1):16-9. PMID:21208155

http://www.drugs.com/clinical_trials/phase-1-studies-show-promise-quatrx-s-novel-compound-sobetirome-lowering-ldl-cholesterol-levels-3279.html

Phase II trial (LDL lowering in FH)

http://www.clinicaltrials.gov/ct2/results?term=eprotirome

mipomersen

Two anti-apoB100 (i.e., ISIS 301012 and ISIS 147764) and one anti-apolipoprotein(a) (i.e., ASO 144367 ur J Intern Med. 2011 Dec;22(6):541-6. Epub 2011 Jul 30. Antisense therapy in the treatment of hypercholesterolemia. Lippi G, Favaloro EJ. PMID:22075277

citations

 Merki E, et al. Antisense oligonucleotide directed to human apolipoprotein B-100 reduces lipoprotein(a) levels and oxidized phospholipids on human apolipoprotein B-100 particles in lipoprotein(a) transgenic mice. Circulation. 2008 Aug 12;118(7):743-53. 

 Akdim F, et al. Eur Heart J. 2011 Nov;32(21):2650-9. Epub 2011 May 18.

Efficacy of apolipoprotein B synthesis inhibition in subjects with mild-to-moderate hyperlipidaemia.

anticoagulants

antiplatelet meds and DTIs- recent studies