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| Sam Mirza Safavi | |
|---|---|
 Depiction of Sam Mirza in a copied manuscript of The Divan of Hafez, made by Soltan Mohammad in c. 1527 | |
| Governor of Herat | |
| 1st tenure | 1521–1530 |
| Predecessor | Ebrahim Soltan Khan Mowsellu |
| Successor | Bahram Mirza Safavi |
| Guardian | Durmish Khan Shamlu Hoseyn Khan Shamlu |
| 2nd tenure | 1533–1536 |
| Predecessor | Bahram Mirza Safavi |
| Successor | Khalifeh Soltan Shamlu |
| Guardian | Aghzivar Khan Shamlu |
| Born | 1517 Iran |
| Died | 1566/67 Qahqaheh Castle, Iran |
| Spouse | Daughter of Hoseyn Khan Shamlu |
| Issue | Rostam Mirza Unnamed daughter |
| Dynasty | Safavid |
| Father | Ismail I |
| Mother | Unnamed Georgian woman |
| Religion | Twelver Shia Islam |
| Writing career | |
| Language | Persian |
| Notable works | Tazkera-ye tohfa-ye Sami |
Sam Mirza Safavi (Persian: سام میرزا صفوی), was a Safavid prince and poet in 16th-century Iran, who wrote the Tazkera-ye tohfa-ye Sami, a collection of biographies of contemporary Persian poets. He was the third son of Shah Ismail I (r. 1501–1524), the founder of the Safavid dynasty.