| Small Cajal body specific RNA 10 | |
|---|---|
| SCARNA10 | |
| Identifiers | |
| Symbol | SCARNA10 |
| Other data | |
| RNA type | Gene; snRNA; snoRNA; scaRNA; |
| PDB structures | PDBe |
In molecular biology, Small Cajal body specific RNA 10 (also known as SCARNA10 or U85) is a small nucleolar RNA found in Cajal bodies. It is predicted to pseudouridylate residue 46 and methylate residue 45 in U5 spliceosomal RNA.
scaRNAs are a specific class of small nucleolar RNAs that localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.[1]
U85 is composed of a H/ACA box domain as well as a C/D box domain, and shows an important structural similarity to SCARNA12. Further it contains two CAB boxes that promotes its localization into the Cajal bodies. Originally detected in human[2], it can be traced through most of the metazoan phyla. In deuterostomes, SCARNA10 is consistently found in an intron of the NCAPD2 gene. Its Drosophila homolog is located in an intron of CG1142, a gene of unknown function that can be identified as a homolog of NCAPD2 by sequence alignment. The discovery of complete SCARNA10 homologs in several lophotrochozoan taxa suggests that SCARNA10 has lost its box C/D box domain in nematodes.
References
edit- ^ Darzacq, X.; Jády, B. E.; Verheggen, C.; Kiss, A. M.; Bertrand, E.; Kiss, T. (2002). "Cajal body-specific small nuclear RNAs: a novel class of 2'-O-methylation and pseudouridylation guide RNAs". EMBO J. 21 (11): 2746–2756. doi:10.1093/emboj/21.11.2746. PMC 126017. PMID 12032087.
{{cite journal}}: CS1 maint: date and year (link) - ^ Kiss, Arnold M.; Jády, Beáta E.; Bertrand, Edouard; Kiss, Tamás (2004). "Human Box H/ACA Pseudouridylation Guide RNA Machinery". Molecular and Cellular Biology. 24 (13): 5797–5807. doi:10.1128/MCB.24.13.5797-5807.2004. PMC 480876. PMID 15199136.