| Small Cajal body specific RNA 13 | |
|---|---|
 SCARNA13 | |
| Identifiers | |
| Symbol | SCARNA13 |
| Rfam | RF00231 |
| Other data | |
| RNA type | Gene; snRNA; snoRNA; scaRNA; |
| PDB structures | PDBe |
In molecular biology, Small Cajal body specific RNA 13 (also known as scaRNA13 or U93) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U2 and U5 spliceosomal RNA.
scaRNAs are a specific class of small nucleolar RNAs that localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.[1]
U93 is composed of two tandemly arranged box H/ACA box sequence motifs and belongs to the H/ACA box class of guide RNAs [2]. U93 is predicted to guide pseudouridylation of U2 spliceosomal snRNA residue U54 and residue U53 of snRNA U5 [2][3][4].
With a size of 252 nt (Tetraodon) and 274 nt (Echinops) it perfectly matches the expectation for a duplicated box H/ACA box snoRNA. In both Tetrapoda and teleosts it is located in a poorly characterized non-coding host gene SNHG10, downstream of the highly conserved GLRX5 gene. In contrast to SCARNA9 the two H/ACA components might be distant homologs, suggesting that this dual snoRNA arose from a tandem duplication of a canonical H/ACA snoRNA.
References
edit- ^ Darzacq, Xavier; Jády, Beáta E.; Verheggen, Céline; Kiss, Arnold M.; Bertrand, Edouard; Kiss, Tamás (2002). "Cajal body-specific small nuclear RNAs: A novel class of 2'-O-methylation and pseudouridylation guide RNAs". The EMBO Journal. 21 (11): 2746–2756. doi:10.1093/emboj/21.11.2746. PMC 126017. PMID 12032087.
- ^ a b Kiss AM, Jády BE, Darzacq X, Verheggen C, Bertrand E, Kiss T (2002). "A Cajal body-specific pseudouridylation guide RNA is composed of two box H/ACA snoRNA-like domains". Nucleic Acids Res. 30 (21): 4643–9. doi:10.1093/nar/gkf592. PMC 135803. PMID 12409454.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Lestrade, Laurent; Weber, Michel J. (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research. 34 (Supplement 1: Database Issue): D158–D162. CiteSeerX 10.1.1.105.7552. doi:10.1093/nar/gkj002. PMC 1347365. PMID 16381836.
- ^ Schattner, P.; Barberan-Soler, S.; Lowe, T. M. (January 2006). "A computational screen for mammalian pseudouridylation guide H/ACA RNAs". RNA. 12 (1): 15–25. doi:10.1261/rna.2210406. PMC 1370881. PMID 16373490.