| Small Cajal body specific RNA | |
|---|---|
| File:.jpg | |
| Identifiers | |
| Other data | |
| RNA type | Gene; snRNA; snoRNA; scaRNA; |
| PDB structures | PDBe |
Small Cajal body specific RNA 7 (also known as SCARNA7 or U90) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the methylation of residue 70 of U1 spliceosomal RNA[1].
scaRNAs are a specific class of small nucleolar RNAs that localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.[1]
SCARNA7 has a length ranging from 285 nt in T. guttata to 425 nt in G. aculeatus, a large part of which consists of an exceptionally long and quite well-conserved, roughly symmetric region between C and D', and C' and D box, respectively. The unusual length
is caused by a repetitive G/U insert. SCARNA7 is found throughout all vertebrates, always in the same host gene (KPN4)
[2]
References
edit- ^ a b Darzacq, X. (2002). "Cajal body-specific small nuclear RNAs: a novel class of 2'-O-methylation and pseudouridylation guide RNAs". EMBO J. 21 (11): 2746–2756. doi:10.1093/emboj/21.11.2746. PMC 126017. PMID 12032087.
- ^ "Homo sapiens U90 scaRNA".