- iC3b generated by proteolysis of C3b
- Integrin α chain (CD11b) noncovalently bound to integrin β chain (CD18).
- phagocytosis of microbes opsonized with iC3b
- can bind to ICAM-1 on endothelium cells?
1. Erdei et al. (2019)
- members of the β2-integrin (CD18)
- "β2-integrins are accepted to play important roles in cellular adhesion, migration, phagocytosis, ECM rearrangement and inflammation."
- Expression levels and other functional differences in mice and men assessed
2. Vorup-Jensen & Jensen (2018)
- Analysis of structural CR3
- CR3 and CR2 work together to become an antigen presenting mechanism
- MIDAS
- "CR3 as inclined to bind positively charged species"
- CR3 and CR4 in NK --> complement-dependent cell cytotoxicity --> biological therapy
3. Rotshenker (2003)
- Regulation of complement-receptor-3
- Injury and disease in CNS and PNS?
- "CR3/MAC-1-mediated myelin phagocytosis is regulated in microglia and macrophages"
4. van Lookeren Campagne et al. (2007)
- "C3b is further degraded to iC3b, C3c and C3dg, products that serve as ligands for selective complement receptors on leukocytes."
- Other useful background
5. Ross & Vĕtvicka (1993)
- intercellular adhesion molecule-1 (ICAM-1)
- LPS binding (PRR)
6. Roberts et al. (2016)
- "Leukadherin‐1 is a specific small‐molecule CR3 agonist that has shown therapeutic promise in animal models of vascular injury and inflammation."
7. Doz-Deblauwe et al. (2019)
- CR3 engaged by PGL-I promotes infection.
8. Agramonte‐Hevia et al. (2006)
- Gram-negative bacteria interaction with phagocytic cells through CR3.
- "Bordetella takes advantage of the CR3 function and uses it to enter into macrophages leading to bacterial survival."
9. Tanya & Mayadas (2016)
- "pro-inflammatory molecule"
- immunoregulatory roles