Immcarle3

This user is a student editor in Wikipedia:Wiki_Ed/Carleton_College/Immunology_(Winter).
Student assignments should always be carried out using a course page set up by the instructor. It is usually best to develop assignments in your sandbox. After evaluation, the additions may go on to become a Wikipedia article or be published in an existing article.

Finalized Topic

C3a (complement)

This page has some good information that highlights some of the basic roles of C3a, but is highly disorganized and does not contain comprehensive information at all. I would like to add more about structure and elucidate relevant mechanisms.

Bibliography

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C3a (complement) Draft

Structure

C3a is a molecule made up of 77 amino acids with three disulfide bonds http://www.sciencedirect.com/science/article/pii/S0003986108004505

http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=CitingArticles&qid=1&SID=2AMC3wE9lhcwgY1anXI&page=2&doc=11&cacheurlFromRightClick=no

http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=CitingArticles&qid=1&SID=2AMC3wE9lhcwgY1anXI&page=1&doc=2&cacheurlFromRightClick=no

http://apps.webofknowledge.com/summary.do?product=WOS&parentProduct=WOS&search_mode=CitingArticles&parentQid=&qid=1&SID=2AMC3wE9lhcwgY1anXI&&page=2

http://www.sciencedirect.com/science/article/pii/S0960894X15301475

Interested Preliminary Topics

The three topics I would be most interested in editing include: 1) Helminth protein: This article does not have any "talk" other than that it is a molecular article. While there are only a few sentences on the article page now, from a little research online, it seems like there are ample resources for developing a much fuller article.

2) Antibody opsonization: This stub has a little more information but is very disorganized and has questionable information (as brought up by somebody on the Talk page). It would also intersect with what we have talked about in class so far and would provide an interesting starting point for further exploration.

3) Complement 4 deficiency: This would be an interesting medical article to try to flesh out that could be modeled after other disease articles.

^ Merle, NS; Noe, R; Halbwachs-Mecarelli, L; Fremeaux-Bacchi, V; Roumenina, LT (2015). "Complement System Part II: Role in Immunity". Frontiers in immunology. 6: 257. PMID 26074922.
^ Strainic, MG; Liu, J; Huang, D; An, F; Lalli, PN; Muqim, N; Shapiro, VS; Dubyak, GR; Heeger, PS; Medof, ME (March 2008). "Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells". Immunity. 28 (3): 425–35. PMID 18328742.
^ Sacks, SH (March 2010). "Complement fragments C3a and C5a: the salt and pepper of the immune response". European journal of immunology. 40 (3): 668–70. PMID 20186746.
^ Leslie, JD; Mayor, R (February 2013). "Complement in animal development: unexpected roles of a highly conserved pathway". Seminars in immunology. 25 (1): 39–46. PMID 23665279.
^ Lambris, JD; Tsokos, GC (1986). "The biology and pathophysiology of complement receptors". Anticancer Research. 6 (3 Pt B): 515–23. PMID 2943215.

[1] Merle, NS; Noe, R; Halbwachs-Mecarelli, L; Fremeaux-Bacchi, V; Roumenina, LT (2015). "Complement System Part II: Role in Immunity". Frontiers in immunology. 6: 257. PMID 26074922.

[2] Strainic, MG; Liu, J; Huang, D; An, F; Lalli, PN; Muqim, N; Shapiro, VS; Dubyak, GR; Heeger, PS; Medof, ME (March 2008). "Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells". Immunity. 28 (3): 425–35. PMID 18328742.

[3] Sacks, SH (March 2010). "Complement fragments C3a and C5a: the salt and pepper of the immune response". European journal of immunology. 40 (3): 668–70. PMID 20186746.

[4] Leslie, JD; Mayor, R (February 2013). "Complement in animal development: unexpected roles of a highly conserved pathway". Seminars in immunology. 25 (1): 39–46. PMID 23665279.

[5] Lambris, JD; Tsokos, GC (1986). "The biology and pathophysiology of complement receptors". Anticancer Research. 6 (3 Pt B): 515–23. PMID 2943215.

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