| Ribosomal protein L19 leader | |
|---|---|
 Predicted secondary structure and sequence conservation of L19_leader | |
| Identifiers | |
| Symbol | L19_leader |
| Rfam | RF00556 |
| Other data | |
| RNA type | Cis-reg; leader |
| Domain(s) | Bacteria |
| SO | SO:0000233 |
| PDB structures | PDBe |
L19 Ribosomal protein leaders are part of the ribosome biogenesis. They were used as an autoregulatory mechanism to control the concentration of ribosomal proteins L19. This family is a putative ribosomal protein leader autoregulatory structure[1] found in B. subtilis and other low-GC Gram-positive bacteria. It is located in the 5′ untranslated regions of mRNAs encoding ribosomal protein L19 (rplS). More examples were predicted in Flavobacteria[2] or Firmicutes[3] with bioinformatic approaches. The structures of all these predicted L19 ribosomal leaders are similar.
References
edit- ^ Zengel JM, Lindahl L (1994). "Diverse mechanisms for regulating ribosomal protein synthesis in Escherichia coli". Progress in Nucleic Acid Research and Molecular Biology. Progress in Nucleic Acid Research and Molecular Biology. 47: 331–370. doi:10.1016/S0079-6603(08)60256-1. ISBN 978-0-12-540047-3. PMID 7517053.
- ^ Eckert, I; Weinberg, Z (24 May 2020). "Discovery of 20 novel ribosomal leader candidates in bacteria and archaea". BMC Microbiology. 20 (130). doi:10.1186/s12866-020-01823-6.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Yao, Z; Barrick, J; Weinberg, Z; Neph, S; Breaker, R; Tompa, M; Ruzzo, WL (2007). "A computational pipeline for high-throughput discovery of cis-regulatory noncoding RNA in prokaryotes". PLoS Comput Biol. 3 (7). doi:10.1371/journal.pcbi.0030126.
{{cite journal}}: CS1 maint: unflagged free DOI (link)
External links
editCategory:Ribosomal protein leader
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