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Membranous nephropathy ... A kidney disorder leading to changes and inflammation of the structures inside the kidney. These structures help filter wastes and fluids. The inflammation may lead to problems with kidney function. Membranous nephropathy is caused by the thickening of part of the glomerular basement membrane (GBM). The glomerular basement membrane is the basal laminal portion of the glomerulus, the glomerulus /ɡlohˈmerələss/ is a network (tuft) of capillaries that performs the first step of filtering blood. The glomerular basement membrane is a part of the kidneys that helps filter waste and extra fluid from the blood. The Glomerular capillary endothelial cells, the GBM and the filtration slits between the podocytes, (or visceral epithelial cells, perform the filtration function of the glomerulus, separating the blood in the capillaries from the filtrate that forms in Bowman's capsule.[1] The GBM is a fusion of the endothelial cell and podocyte basal laminas. [2]The exact reason for this thickening is not known. The thicker glomerular membrane does not work normally. Large amounts of protein are lost in the urine as a result. This condition is one of the most common causes of nephrotic syndrome. It may be a primary kidney disease, or it may be associated with other conditions.
References
editJarad, G.; Miner, J. H. (2009). "Update on the glomerular filtration barrier". Current opinion in nephrology and hypertension. 18 (3): 226–232. PMC 2895306. PMID 19374010.
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