The organochlorine PCP (pentachlorophenol, C6Cl5OH) is a wood preservative biocide.
Structure
editPCP is a polychlorinated acromatic:
Degradation
editPCP is degraded by some bacteria, including Sphingobacterium chlorophenolicum [1] [2]
PCP → TCHQ → TriCHQ → DCHQ → 2,4-dichloro-3-hydroxy-cis,cis-muconic semialdehyde
References
edit- ^ Copley Sd (2000). "Evolution of a metabolic pathway for degradation of a toxic xenobiotic: the patchwork approach". Trends in Biochemical Sciences. 25: 261–265. doi:10.1016/S0968-0004(00)01562-0.
- ^ Mbengue, Alassane; Bhattacharjee, Souvik; Pandharkar, Trupti; Liu, Haining; Estiu, Guillermina; Stahelin, Robert V.; Rizk, Shahir S.; Njimoh, Dieudonne L.; Ryan, Yana; Chotivanich, Kesinee; Nguon, Chea; Ghorbal, Mehdi; Lopez-Rubio, Jose-Juan; Pfrender, Michael; Emrich, Scott; Mohandas, Narla; Dondorp, Arjen M.; Wiest, Olaf; Haldar, Kasturi (15 April 2015). "A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria". Nature. 520 (7549): 683–687. doi:10.1038/nature14412.