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- Eagan, Seamus, musician
- Earl, Robert Stephen, (1903-1910)
- Easton, Charles F., poet
- Eberhart, Mignon G., (died 1996), author
- Eberle, Ray, (died 1979), jazz musician
- Ebert, Carl, (1887-1980), opera manager and director
- Eckmann, Otto, (1865-1902), painter, interior designer
- Economaki, Chris, (born 1920), auto-racing reporter
- Eddy, Don, painter
- Edghill, Rosemary, mystery author
- Edlow, April, (born 1976), African American artist and photographer
- Edmonds, Kenneth 'Babyface', (born 1958), music & film producer
- Edmund of Abingdon, scholastic philosopher
- Edsige, Archbishop of Canterbury
- Edwards, Donald, musician
- Edwards, John Cummins, (1804-1888), American politician & Missouri governor
- Edwards, Julian, (died 1910), composer
- Edwards, Ned, squash player
- Edwards, Ralph, (born 1913), television host
- Edwards, Ross, (born 1943), composer
- Edwardson, John, airline manager
- Eenpalu, Kaarel, Estonian politician
- Eggelbrecht, Axel, (1899-1991), journalist
- Egk, Werner, (1901-1983), composer
- Ehlvest, Jüri, Estonian chess player
- Ehmke, Horst, German SPD politician
- Ehre, Ida, (1900-1989), actress
- Ehrenburg, Ilya Gregoryevich, (1891-1947), novelist, war correspondent
- Ehrenmark, Torsten, Swedish writer
- Eibisch, Eugeniusz, Polish painter
- Eichhorn, Hermann von, German soldier
- Eirenicus, Theodore, patriarch of Constantinople
- Ekelund, Vilhelm, Swedish writer
- Eldridge, John S., American railroad manager
- Eleutherius of Alexandria, Patriarch of Alexandria
- Elf, Mark, musician
- Elgaard, Ray, Canadian athlete
- Elgart, Bill, musician
- Elgart, Les, (born 1918), musician, bandleader
- Elizabeth, Countess of Sutherland, (fl. early 19th century), Scottish landlord
- Elizabeth, Queen of Belgium, (died 1965)
- Eller, Fran, (1873-1956), poet
- Eller, Heino, Estonian composer
- Ellert, Gundi, dramatist, author
- Ellie, Edward S., American novelist
- Ellington, Mercer, (1919-1996), American musician, composer
- Elliott, Sam, (born 1944), actor
- Ellis, Bret Easton, American author
- Ellis, Jim, (died 2001), network designer
- Ellis, Perry, (died 1986), fashion designer
- Elsass, Peter, Danish anthropologist
- Elsheimer, Adam, (1578-1610), painter
- Elstner, Frank, (born 1942), television producer
- Elts, Olari, Estonian conductor
- Emerson, Kathy, historical novelist
- Emery, Vic, Canadian bobsleigh racer
- Eormenric, (534-564), King of Kent
- Eppler, Erhard, German SPD politician
- Ergma, Ene, Estonian astronomer and politician
- Erickson, Cal, computer scientist
- Erickson, Dennis, American football coach
- Erkendfried, scholastic philosopher
- Errázuriz, F., Chilean president
- Errázuriz, Germán Riesco, Chilean president
- Ertl, Josef, FDP politician
- Escheté, Ron, musician
- Escoude, Christian, musician
- Eskenazi, Rosa, musician
- Espriu, Salvador, writer
- Essen, Hans Henrik von, Count, (1814-1816), Norwegian Prime Minister
- Estes, Richard, (born 1936), painter
- Etaix, Pierre, (born 1928), actor, film director and writer
- Etcheverry, Sam, Canadian football player
- Eubanks, Robin, American musician
- Eugenius I, Patriarch, patriach of Constantinople
- Eugenius II, Patriarch, patriarch of Constantinople
- Eulogius I of Alexandria, Patriarch of Alexandria
- Eusebius (Maronite Patriarch)
- Eustathius Garidas, Patriarch, patriarch of Constantinople
- Eustatius of Alexandria, Patriarch of Alexandria
- Euthymius I, Patriarch, patriarch of Constantinople
- Euthymius II, Patriarch, patriarch of Constantinople
- Eutychius of Alexandria, Patriarch of Alexandria
- Euzois, patriarch of Constantinople
- Evans, Abbie Huston, poet
- Ever, Ita, Estonian actress
- Everard of Ypres, scholastic philosopher
- Everon, C. J., (born 1971), historian and novelist
- Everswine, Richard, poet
- Everts, Stefan, motorcross racer
- Ewart, Galvin, poet
- Eyck, Aldo van, (died 1999), architect
- Eyre, Elizabeth, author