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Assignment #1 Wikipedia

Wikipedia'sFive Pillars

Wikipedia abides by the five distinct principles listed below:

1. Wikipedia is an encyclopedia

2. Wikipedia entries are written in a neutral point of view

3. Wikipedia is free: advertisement and spam are not tolerated

4. Wikipedians should respect one another

5. Wikipedia does not have firm rules

Unit 5: Practicing Citations

Neuropharmacological specificity of brain structures involved in soman-induced seizures.

In this study three different classes of drugs with known anticonvulsant effects are evaluated when given i.c (intracerebral) and in distinct brain regions.^[1] The purpose in determine whether these drugs injected directly into specific brain regions will have an effect on neuropathology. Microdialysis surgery was performed on animals to make intracerebral injections possible. It was determined that the dosage of the treatment drugs needed to mitigate anticholinergic affects varied significantly among brain regions. In conclusion, the study supports the idea that unique neuropathological pathways are involved in specific brain regions

ChemR23 knockout mice display mature-onset mild obesity but no deficit in adipocyte differentiation.

Chemerin is a protein that is believed to be involved in the regulation of adipocyte differentiation.^[2] The purpose of this study was to determine if this is actually the case. A knockout model was believed to be the best method for investigation. Knockout mice for the protein Chem23, the receptor of Cherin, were used in the study. It was determined that bodyweight was unaffected up until 12 months. Mice older than 12 months had significantly more bodyweight and were categorized as obese. It has been concluded in this study that Chemerin plays an important role in metabolism as well as in the regulation of adipocyte differentiation.^[2]

References

^ Skovira, J. W.; Shih, T. M.; McDonough, J. H. (2012 Jun). "Neuropharmacological specificity of brain structures involved in soman-induced seizures". Neurotoxicology. 33 (3): 463–8. doi:10.1016/j.neuro.2012.03.006. PMID 22774227. {{cite journal}}: Check date values in: |date= (help)
^ ^a ^b Rouger, L.; Denis, G. R.; Luangsay, S.; Parmentier, M. (2013 Oct 1). "ChemR23 knockout mice display mature-onset mild obesity but no deficit in adipocyte differentiation". The Journal of Endocrinology. 219 (3): 279–289. doi:10.1530/JOE-13-0106. PMID 24084834. S2CID 28568031. {{cite journal}}: Check date values in: |date= (help)

[1] Skovira, J. W.; Shih, T. M.; McDonough, J. H. (2012 Jun). "Neuropharmacological specificity of brain structures involved in soman-induced seizures". Neurotoxicology. 33 (3): 463–8. doi:10.1016/j.neuro.2012.03.006. PMID 22774227. {{cite journal}}: Check date values in: |date= (help)

[Rouger-2] Rouger, L.; Denis, G. R.; Luangsay, S.; Parmentier, M. (2013 Oct 1). "ChemR23 knockout mice display mature-onset mild obesity but no deficit in adipocyte differentiation". The Journal of Endocrinology. 219 (3): 279–289. doi:10.1530/JOE-13-0106. PMID 24084834. S2CID 28568031. {{cite journal}}: Check date values in: |date= (help)

[1]

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