Manu Malik as Omkarnath Maheshwari: Bhairavi's son; Vishambharnath's brother; Sunaina's husband; Anshuman's father; Nishant's grandfather. (2009–2018)
Ather Habib / Yash Gera / Samir Sharma as Shaurya Maheshwari: Rajshri and Vishambharnath's son; Akshara's brother; Varsha's husband; Ananya's father. (2009–2017)
Pooja Joshi Arora as Varsha Maheshwari: Sulekha's daughter; Shaurya's wife; Akshara's best friend; Ananya's mother. (2009–2020)
Aman Sharma / Dheeraj Gumbar as Anshuman Maheshwari: Sunaina and Omkar's son; Jasmeet's husband; Nishant's father. (2009–2016)
Soniya Kaur / Shirin Sewani as Jasmeet Kaur Maheshwari: Sukhwinder and Pammi's daughter; Anshuman's wife; Nishant's mother. (2013-2018)
Nairtiya Chandola / Akshaya Naik as Ananya Maheshwari Sharma: Varsha and Shaurya's first daughter; Kuhu's elder sister; Ranveer's wife; Ramya's mother. (2012–2018)
Arjun Kohli as Ranveer Sharma: Ananya's husband; Ramya's father. (2016–2018)
Khushmeet Gill / Anmol Jyotir / Vatsal Sheth as Nishant Maheshwari / Nannu / Nish: Anshuman and Jasmeet's son; Mishti's ex fiancee; Ketki's husband; Kukki's father. (2015-2019)
Trishaa Chatterjee as Ketki Rajvansh Maheshwari / Ketu: Nidhi and Kaushal's daughter; Atul's sister; Abir and Kunal's cousin; Ved and Varun's ex fiancee; Nishant's wife; Kukki's mother. (2019–2020)
Urmila Sharma / Sunitha Rao as Rukmini Agrawal: Mohit and Koel's mother; Yash's adoptive grandmother; Anmol's grandmother. (2009–2021)
Nidhi Uttam as Nandini Singhania Agarwal: Kaveri and Mahendra's daughter; Mohit's wife; Yash's adoptive mother; Anmol's mother. (2009–2019)
Ayush Agarwal / Shamik Abbas as Mohit Agrawal: Rukmini's son; Koel's brother; Nandini's husband; Yash's adoptive father; Anmol's father. (2009–2019)
Suzanne Bernert as Martha Wilkins: Tejasvini's daughter; Rose's mother. (2016)
Ansh Kaul / Sanchit Sharma as Yash Agrawal: Prena and Ankit's son; Nandini and Mohit's adopted son; Anmol's adoptive brother; Sanajana's ex fiancee; Rose's husband; Asher's father. (2012–2017)
Vaishali Takkar as Sanjana / Sanju: Naksh's girlfriend; Yash's ex fiancee. (2015)
Sippora Zoutewelle as Rose Wikins Agrawal: Martha's daughter; Yash's wife; Asher's mother. (2016)
Karan Pahwa as Anmol Agrawal: Nandini and Mohit's son; Yash's step-brother; Mansi's husband; Manav's father. (2016, 2018–2019)
Unknown as Pungi: Naira's friend. (2016)
Shreya Sharma / Vaishnavi Rao as Mansi Goenka Agarwal: Akhilesh and Surekha's daughter; Luv and Kush's sister; Anmol's wife; Manav's mother; Molested by Puru mama. (2017–2019)
Sandeep Mehta as Rajshekhar "Raj" Singhania: Mahendra's brother; Gayatri and Devyani's husband; Naitik and Rashmi's father; Muskaan and Naman's step-father; Naksh, Saanjh and Naira's grandfather. (2009–2018)
Sonali Verma as Gayatri Singhania: Rajshekar's first wife; Naitik and Rashmi's mother; Naksh, Saanjh and Naira's grandmother. (2009–2013) (Dead)
Hina Khan as Akshara Maheshwari Singhania: Rajshree and Vishambharnath's daughter; Shaurya's sister; Naitik's wife; Naksh and Naira's mother. (2009–2016) (Dead)
Karan Mehra / Vishal Singh as Naitik Singhania: Gayatri and Rajshekar's son; Rashmi's brother; Akshara's husband; Naksh and Naira's father; Priyanka's patient. (2009–2018)
Tiya Gandwani as Priyanka: Soumya's younger sister; Keerti and Kartik's maternal aunt; Naitik's doctor and care taker. (2017–2019)
Bani / Shivansh Kotia / Rohan Mehra / Rishi Dev / Shehzad Shaikh as Naksh Singhania / Duggu / Lalla / Chikku / Nic: Akshara and Naitik's son; Naira's brother; Keerti's husband; Aarav and Krish's father and Tara's ex fiancee. (2012–2021)
Mohena Singh / Harsha Khandeparkar as Keerti Goenka Singhania / Keerti Goenka Bansal: Soumya and Manish's daughter; Swarna's step-daughter; Kartik's elder sister; Shubam's half elder sister; Naksh's wife; Aarav and Krish's mother; Aditya's ex fiancee. (2016–2021)
Umang Jain as Tara Shekhawat: Naksh's ex fiancee. (2015)
Romit Sharma as Aditya Bansal: Keerti's ex fiancee. (2016-2021)
Dwiti Gajera / Saksham Vasu as Krish Singhania / Krishna: Keerti and Naksh's son. (2019–2021)
Neha Saroopa as Rashmi Singhania Desai: Gayatri and Rajshekar's daughter; Naitik's sister; Nikhil and Sameer's wife; Saanjh's mother. (2009-2016) (Dead)
Ashish Kapoor as Nikhil Deora: Rashmi's ex husband; Rajendra and Rama's son; Saanjh's father. (2011–2013)
Diksha Dhami as Trisha: Naira's friend; Molested by Abhishek, Luv, Kush; Veeru's father. (2020)
Payal Bhojwani / Kanchi Singh / Deblina Chatterjee / Simran Khanna as Saanjh Deora Goenka / Gayatri / Gayu: Rashmi and Nikhil's daughter; Vivaan's ex fiancée; Samarth's ex wife; Vansh, Arjun, Vatsal's mother. (2015–2021)
Samir Onkar as Samarth Goenka: Suhasini's nephew, Manish and Akhilesh's younger cousin; Riddhima and Saanjh's ex husband; Vansh, Arjun and Vatsal's father. (2018–2020)
Fahad Ali as Vivaan: Saanjh's ex fiancee; Vansh's father. (2016)
Vrushika Mehta as Dr Riddhima: Kairav's psychiatrist; Samarth's ex fiancee. (2020)
Maaz Champ / Siddharth Dubey / Sharan Anandani as Vansh Goenka: Saanjh and Samarth's son; Arjun and Vatsal's elder brother.(2019–present)
Niharika Chouksey as Nishtha Birla: Mahima and Anand's daughter; Parth's younger sister. (2021–present)
Ashish Nayyar as Dr. Anand Birla: Heart surgeon; Harshvardhan's younger brother; Mahima's husband; Parth and Nishtha's father. (2021–present)
Neeraj Goswami as Dr. Parth Birla: Doctor by degree; musician by choice; Mahima and Anand's son; Nishtha's elder brother; Shefali's husband. (2021–present)
Sehrish Ali as Shefali Birla: Journalist; Parth's wife. (2021–present)
Ami Trivedi as Manjari Birla: Mahima's elder sister; Harshvardhan's wife; Abhimanyu and Neil's mother. (2021–present)
Vinay Jain as Dr. Harshvardhan Birla: PHD doctor; Anand's elder brother; Manjari's husband; Abhimanyu and Neil's father. (2021–present)
Kairav Waghela / Prachi Thakur / Pranali Rathod as Kaira Goenka Birla / Akshara / Akshu: Singer and musician; Naira and Kartik's second daughter; Krishna and Kairav's younger sister and Aarohi's elder sister; Abhimanyu's wife. (2020–present)[15]
Harshad Chopda as Dr. Abhimanyu Birla / Abhi: Surgeon at Birla Hospital and Medical Institute; Manjari and Harshvardhan's first son; Neil's elder brother; Kaira's husband. (2021–present)[16]
Siya Makwana / Karishma Sawant as Dr. Aarohi Goenka Birla / Aaru / Kairat / Chipkali: Naira and Kartik's third daughter; Krishna, Kairav and Kaira's younger sister; Neil's wife. (2021–present)[17]
Paras Priyadarshan as Neil Birla / Chamagaadad: Manjari and Harshvardhan's younger son; Abhimanyu's younger brother and Aarohi's husband. (2021–present)
Pragati Mehra as Dr. Mahima Birla: Heart surgeon; Manjari's younger sister; Anand's wife; Parth and Nishtha's mother. (2021–present)