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Coiled-coil domain-containing protein 120 (CCDC120), also known as JM11 protein, is a protein that, in humans, is encoded by the CCDC120 gene.^[1] The function of CCDC120 has not been formally identified but there are indications that it may somehow be linked to Breast Cancer. Structural components, conservation, and interactions can be identified computationally but there has been little laboratory work on CCDC120.

Gene

The CCDC120 gene is located on human chromosome X, at Xp11.23.^[2] There are six different transcript variants of CCDC120 produced by alternative splicing. ^[3]

Protein

The CCDC120 protein has four different isoforms, ranging from 618 to 696 amino acids in length. ^[4] Isoform 1 is the longest isoform and is encoded by transcript 1 of the CCDC120 gene. ^[5]

Breast Cancer

Gene Conservation

Paralogs

CCDC120 has 3 identifiable paralogs in humans, FERM domain Containing 4A, FERM domain Containing 4B, and C1orf106 (gene).

Gene Expression

Structure

References in Scientific Literature

CCDC120 was found to be upregulated under pulsed electromagnetic fields in human osteoblastlike cells.^[6]

Patterns

The mRNA transcript of CCDC120 contains a 120bp repeat near the 3' end. ^[7]

120bp repeat is visible on the graph.

References

^ "Entrez Gene: CCDC120 coiled-coil domain containing 120 (Homo sapiens)".
^ "Gene Cards: coiled-coil domain containing 120".
^ "NCBI Nucleotide Search: CCDC120 Homo sapiens".
^ [hhttp://www.ncbi.nlm.nih.gov/protein/?term=(ccdc120)+AND+%22Homo+sapiens%22%5Bporgn%3A__txid9606%5D "NCBI Protein Search: CCDC120 Homo sapiens"].
^ "NCBI Protein: coiled-coil domain-containing protein 120 isoform 1 (Homo sapiens)".
^ Sollazzo, Vincenzo; Palmieri, Annalisa; Pezzetti, Furio; Massari, Leo; Carinci, Francesco (2010). "Effects of Pulsed Electromagnetic Fields on Human Osteoblastlike Cells (MG-63): A Pilot Study". Clinical Orthopaedics and Related Research. 468 (8): 2260–2277. doi:10.1007/s11999-010-1341-5. PMC 2895828. PMID PMC2895828. {{cite journal}}: Check |pmid= value (help); Unknown parameter |month= ignored (help)CS1 maint: date and year (link)
^ "Dotlet".