Project Proposal
By: Ashley Tran, Bryan Tan and Seth Kendall
Summary
Discovery
editIn this section we will give a basic overview of the history of the gene including its discovery and advances in our understanding of its function.
Importance
editDescription of the importance to cellular function of the protein.
Location
editDescription of the physical location of the GAB2 gene on the genome and any importance related to this.
Structure
editDescription of the structure of the GAB2 protein.
Function
editMore detailed description of the function of the protein in the cell.
Interactions
editDescriptions of the various interactions of the GAB2 protein. Including interactions with Grb2, PTPN11, PLCG2, RICS, PIK3R1, CRKL, AKT1 and SHC1.
Association with Alzheimer’s Disease
editBrief overview of the body of knowledge linking GAB2 to Alzheimer's Disease.