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User:Logophile59/sandbox/Marian Walhout

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Marian Walhout is a systems biologist who investigates the structure, function and evolution of biological networks. She holds the Maroun Semaan Chair in Biomedical Research at the University of Massachusetts Medical School.[1] Her research uses large-scale data sets and computational modeling to unravel regulatory networks involved in metabolism and development.

Career

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Walhout is known for developing methods and resources for the systems biology community. She produced a public annotated compendium of regulatory transcription factors in C. elegans for use in mapping regulatory networks.[2]  She developed a novel “gene-centered” high-throughput one-hybrid assay to identify interactions between gene promoters and regulatory transcription factors in the C. elegans digestive tract, creating one of the first useful protein-DNA interaction networks and gaining significant insight into the mechanism of differential gene expression in C. elegans and introducing the idea of “master regulators” in the control of metazoan transcription.[3]  The ideas in this paper were foundational for our understanding of gene networks in metazoans, and the yeast one-hybrid method she developed has had considerable impact.  She continues to use the gene-centered approach to gain insight into human disease (see for example Fuxman Bass et al. 2015[4]). She has found that gastrointestinal microbiota may affect an organism's response to chemotherapeutic drugs, using C. elegans as a model system.[5]

Awards

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References

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  1. ^ a b "UMass Medical School faculty appointed to endowed chairs". University of Massachusetts Medical School. 2017-04-12. Retrieved 2019-05-24.
  2. ^ Reece-Hoyes, John S; Deplancke, Bart; Shingles, Jane; Grove, Christian A; Hope, Ian A; Walhout, Albertha JM (2005). "A compendium of Caenhorabditis elegans regulatory transcription factors: a resource for mapping transcription regulatory networks". Genome Biology. 6 (13): R110. doi:10.1186/gb-2005-6-13-r110. ISSN 1465-6906. PMC 1414109. PMID 16420670.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  3. ^ Deplancke, Bart; Mukhopadhyay, Arnab; Ao, Wanyuan; Elewa, Ahmed M.; Grove, Christian A.; Martinez, Natalia J.; Sequerra, Reynaldo; Doucette-Stamm, Lynn; Reece-Hoyes, John S.; Hope, Ian A.; Walhout, Albertha J.M. (2006-06-13). "A Gene-Centered C. elegans Protein-DNA Interaction Network". Cell. 125 (6): 1193–1205. doi:10.1016/j.cell.2006.04.038. ISSN 0092-8674.
  4. ^ Fuxman Bass, Juan I.; Sahni, Nidhi; Shrestha, Shaleen; Garcia-Gonzalez, Aurian; Mori, Akihiro; Bhat, Numana; Yi, Song; Hill, David E.; Vidal, Marc; Walhout, Albertha J.M. (2015-04-XX). "Human Gene-Centered Transcription Factor Networks for Enhancers and Disease Variants". Cell. 161 (3): 661–673. doi:10.1016/j.cell.2015.03.003. PMC 4409666. PMID 25910213. {{cite journal}}: Check date values in: |date= (help)CS1 maint: PMC format (link)
  5. ^ "Your Gut Bacteria May Effect Your Response to Chemotherapy Drugs". Cancer Research from Technology Networks. Retrieved 2019-09-30.
  6. ^ "Senior Scholar Awardees in Aging for 2007 | The Lawrence Ellison Foundation". www.ellisonfoundation.org. Retrieved 2019-05-24.
  7. ^ "Chancellor's Medal for Distinguished Teaching recipient Anne Gilroy to deliver Last Lecture". University of Massachusetts Medical School. 2018-04-19. Retrieved 2019-05-24.
  8. ^ "Riccio Fund for Neuroscience awards first research grants". University of Massachusetts Medical School. 2018-06-20. Retrieved 2019-05-24.
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