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HW for 9th week (3/7)
- Peer review: nicotanimide, RNA pol II
- Look for...
- Clarity
- completeness of coverage
- organization
- media
- linked words
- redundancy
- sources
- Look for...
Intentions for Edit of Phosphatase Article
I want to improve and expound upon the following aspects of the enzyme phosphatase:
- Write a more detailed general description of the enzyme that addresses its general function, what class of enzymes it belongs to, and a brief overview of its roles in the body.
- Explore the general catalytic mechanism of phosphatase.
- Address significant aspects of physiological relevance
- Write in greater detail about 3 major types of phosphatase, including definition, mechanism, and physiological relevance. Briefly discuss sub-classes.
- Protein phosphatase
- Mechanism
- Subtypes: Ser/Thr, His, metallo-dependent
- Role in signal transduction cascades, protein regulation,
- Alkaline phosphatase
- Mechanism
- Roles in digestion, agriculture, cancer
- Alkaline phosphatase
- Mechanism
- Roles in intestinal homeostatis, liver/bone/kidney, and developmental biology
- Protein phosphatase
- Briefly overview significant uses of phosphatase inhibitors in drugs
Preliminary Bibliography
- Fundamentals of Biochemistry; Voet, Voet, and Pratt (ISBN 978-1-118-91840-1)[1]
- Direct determination of phosphatase activity from physiological substrates in cells (DOI: 10.1371/journal.pone.0120087).[2]
- Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (DOI: 10.1126/scisignal.2004712)[3]
- Human HAD phosphatases: structure, mechanism, and roles in health and disease (DOI: 10.1111/j.1742-4658.2012.08633.x) [4]
- How do inhibitory phosphatases work? (PMID 12431385)[5]
Homework due 2/21:
- Check out ChemDraw
- Okay images: self-made, public domain, wikimedia commons, copyrighted w/ free license
- First draft due next week; print hard copy for Dr. Tienson to annotate
- Complete media training
Homework due 2/14:
- Post proposed outline to talk page of phosphatase article.
Homework for next week:
- By tomorrow, update class dashboard name to reflect chosen article.
- By Tuesday, post first five sources of bibliography to user page. (copy DOI, insert)
- WP:REFB
- WP:CITE
Notes
edit- ^ G.,, Voet, Judith; W.,, Pratt, Charlotte. Fundamentals of biochemistry : life at the molecular level. ISBN 9781118918401. OCLC 910538334.
{{cite book}}: CS1 maint: extra punctuation (link) CS1 maint: multiple names: authors list (link) - ^ Ren, Zhongyuan; Do, Le Duy; Bechkoff, Géraldine; Mebarek, Saida; Keloglu, Nermin; Ahamada, Saandia; Meena, Saurabh; Magne, David; Pikula, Slawomir (2015-03-18). "Direct Determination of Phosphatase Activity from Physiological Substrates in Cells". PLOS ONE. 10 (3): e0120087. doi:10.1371/journal.pone.0120087. ISSN 1932-6203. PMC 4364917. PMID 25785438.
{{cite journal}}: CS1 maint: PMC format (link) CS1 maint: unflagged free DOI (link) - ^ Couzens, Amber L.; Knight, James D. R.; Kean, Michelle J.; Teo, Guoci; Weiss, Alexander; Dunham, Wade H.; Lin, Zhen-Yuan; Bagshaw, Richard D.; Sicheri, Frank (2013-11-19). "Protein Interaction Network of the Mammalian Hippo Pathway Reveals Mechanisms of Kinase-Phosphatase Interactions". Science Signaling. 6 (302): rs15. doi:10.1126/scisignal.2004712.
- ^ Seifried, Annegrit; Schultz, Jörg; Gohla, Antje (2013-01-01). "Human HAD phosphatases: structure, mechanism, and roles in health and disease". FEBS Journal. 280 (2): 549–571. doi:10.1111/j.1742-4658.2012.08633.x. ISSN 1742-4658.
- ^ Coggeshall, K. M.; Nakamura, Koji; Phee, Hyewon (2002-12-01). "How do inhibitory phosphatases work?". Molecular Immunology. 39 (9): 521–529. ISSN 0161-5890. PMID 12431385.