Round of 16
edit| 19 January 2021 | FC Volendam (2) | 1–2 (a.e.t.) | PSV (1) | Volendam |
| 21:00 CEST | Stadium: Kras Stadion |
| 19 January 2021 | Vitesse (1) | 1–0 | ADO Den Haag (1) | Arnhem |
| 18:45 CEST | Stadium: GelreDome |
| 20 January 2021 | AZ (1) | 1–2 | Ajax (1) | Alkmaar |
| 21:00 CEST | Stadium: AFAS Stadion |
| 21 January 2021 | NEC Nijmegen (2) | 1–4 | Fortuna Sittard (1) | Nijmegen |
| 18:45 CEST | Stadium: Stadion de Goffert |
| 20 January 2021 | Feyenoord (1) | 0–1 | Heracles Almelo (1) | Rotterdam |
| 18:45 CEST | Stadium: De Kuip |
| 19 January 2021 | MVV Maastricht (2) | 0–1 | Excelsior (2) | Maastricht |
| 14:30 CEST | Stadium: De Geusselt |
| 20 January 2021 | FC Emmen (1) | 0–1 | SC Heerenveen (1) | Emmen |
| 14:30 CEST | Stadium: De Oude Meerdijk |
Quarter-finals
edit| 9 February 2021 | Ajax (1) | 0–1 | Vitesse (1) | Amsterdam |
| Stadium: Johan Cruijff Arena |
| 10 February 2021 | Fortuna Sittard (1) | 0–1 | Heracles Almelo (1) | Sittard |
| Stadium: Fortuna Sittard Stadion |
| 10 February 2021 | Excelsior (2) | 1–0 | PSV (1) | Rotterdam |
| Stadium: Van Donge & De Roo Stadion |
| 11 February 2021 | SC Heerenveen (1) | 0–0 (a.e.t.) (4–3 p) | VVV-Venlo (1) | Heerenveen |
| Stadium: Abe Lenstra Stadion |
Semi-finals
edit| 2 March 2021 | Excelsior (2) | 0–1 | SC Heerenveen (1) | Rotterdam |
| Stadium: Van Donge & De Roo Stadion |
| 3 March 2021 | Heracles Almelo (1) | 0–2 | Vitesse (1) | Almelo |
| Stadium: Erve Asito |
Final
edit| Vitesse (1) | 1–0 | SC Heerenveen (1) |
|---|---|---|