Clinical data | |
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Trade names | Amicar |
Other names | ε-aminocaproic acid, ε-Ahx |
AHFS/Drugs.com | Monograph |
MedlinePlus | a608023 |
License data | |
Routes of administration | By mouth, intravenous |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Metabolism | Kidney |
Elimination half-life | 2 hours |
Identifiers | |
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Chemical and physical data | |
Formula | C6H13NO2 |
Molar mass | 131.175 g·mol−1 |
3D model (JSmol) | |
Melting point | 205 °C (401 °F) |
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Aminocaproic acid, sold under the brand name Amicar among others, is a medication used to treat certain bleeding disorders.[3] This may include bleeding due to fibrinolysis such as may occur following heart surgery, abruptio placentae, liver cirrhosis, and in cancer; bleeding within the eye; and hereditary hemorrhagic telangiectasia.[3][4] It may be taken by mouth or injection into a vein.[4]
Common side effects include nausea, abdominal pain, diarrhea, dizziness, fever, shortness of breath, headache, swelling, and itchiness.[4] Other side effects may include muscle breakdown.[4] It should generally not be used in people with bleeding from within the kidney.[4] Safety in pregnancy is unclear.[4] It is a form of carboxylic acid that decreases fibrinolysis.[4]
Aminocaproic acid was approved for medical use in the United States in 1964.[4] It is available as a generic medication.[6] In the United States 15 pills of 500 mg costs about 44 USD as of 2022.[6]
References
edit- ^ G. J. Reiss (2010). "CSD Communication AMCAPR11: 6-Aminohexanoic acid". Cambridge Structural Database: Access Structures. Cambridge Crystallographic Data Centre. doi:10.5517/ccv38nv. Archived from the original on 2021-11-04. Retrieved 2021-08-18.
- ^ Bodor, Géza; Bednowitz, Allan L.; Post, Ben (1967). "The crystal structure of ε-aminocaproic acid". Acta Crystallographica. 23 (3): 482–490. doi:10.1107/S0365110X67003019.
- ^ a b c d "Amicar- aminocaproic acid solution Amicar- aminocaproic acid tablet". DailyMed. 9 October 2020. Archived from the original on 13 November 2020. Retrieved 11 November 2020.
- ^ a b c d e f g h i "Aminocaproic Acid Monograph for Professionals". Drugs.com. Archived from the original on 12 November 2020. Retrieved 14 January 2022.
- ^ "Aminocaproic acid (Amicar) Use During Pregnancy". Drugs.com. 29 April 2020. Archived from the original on 29 November 2020. Retrieved 11 November 2020.
- ^ a b "Aminocaproic Acid Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 13 October 2016. Retrieved 14 January 2022.