User:Mr. Ibrahem/Calcipotriol

Mr. Ibrahem/Calcipotriol
Clinical data
Trade names	Daivonex, Dovonex, Sorilux, others
Other names	calcipotriene (USAN US)
AHFS/Drugs.com	Monograph
MedlinePlus	a608018
Pregnancy; category	AU: B3; ;
Routes of; administration	Topical
Drug class	Form of vitamin D
Legal status
Legal status	AU: S4 (Prescription only); CA: ℞-only; UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Bioavailability	5 to 6%
Metabolism	Liver
Excretion	Biliary
Identifiers
	IUPAC name (1R,3S,5E)-5-{2-[(1R,3aS,4Z,7aR)-1-[(2R,3E)-5-cyclopropyl-5-hydroxypent-3-en-2-yl]-7a-methyl-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexane-1,3-diol;
Chemical and physical data
Formula	C27H40O3
Molar mass	412.614 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O[C@@H]1CC(\C(=C)[C@@H](O)C1)=C\C=C2/CCC[C@]4([C@H]2CC[C@@H]4[C@@H](/C=C/[C@@H](O)C3CC3)C)C;
	InChI InChI=1S/C27H40O3/c1-17(6-13-25(29)20-8-9-20)23-11-12-24-19(5-4-14-27(23,24)3)7-10-21-15-22(28)16-26(30)18(21)2/h6-7,10,13,17,20,22-26,28-30H,2,4-5,8-9,11-12,14-16H2,1,3H3/b13-6+,19-7+,21-10-/t17-,22-,23-,24+,25-,26+,27-/m1/s1 ; Key:LWQQLNNNIPYSNX-UROSTWAQSA-N ;
	(what is this?) (verify)

Calcipotriol, also known as calcipotriene, is a medication used to treat psoriasis.^[2] It is applied to the skin.^[2] It is also available in combination with betamethasone.^[2]

Common side effects include skin irritation, itchiness, and worsening psoriasis.^[2] Other side effects may include increased sensitivity to UV radiation and high calcium.^[2] Safety in pregnancy is unclear.^[2] It is a manufactured derivative of calcitriol, a form of vitamin D.^[1]

Calcipotriol was patented in 1985 and approved for medical use in 1991.^[3] It is on the World Health Organization's List of Essential Medicines.^[4] It is available as a generic medication.^[5] In the United States 60 grams costs about 70 USD as of 2021.^[5]

References

^ ^a ^b "Calcipotriol". SPS - Specialist Pharmacy Service. 28 April 2015. Archived from the original on 11 October 2021. Retrieved 29 December 2021.
^ ^a ^b ^c ^d ^e ^f ^g ^h "Calcipotriene Monograph for Professionals". Drugs.com. Archived from the original on 26 July 2017. Retrieved 29 December 2021. Cite error: The named reference "AHFS2021" was defined multiple times with different content (see the help page).
^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 452. ISBN 9783527607495. Archived from the original on 2021-01-22. Retrieved 2021-03-03.
^ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
^ ^a ^b "Calcipotriene Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 25 October 2016. Retrieved 29 December 2021.

[SP2021-1] "Calcipotriol". SPS - Specialist Pharmacy Service. 28 April 2015. Archived from the original on 11 October 2021. Retrieved 29 December 2021.

[AHFS2021-2] ^ ^a ^b ^c ^d ^e ^f ^g ^h "Calcipotriene Monograph for Professionals". Drugs.com. Archived from the original on 26 July 2017. Retrieved 29 December 2021. Cite error: The named reference "AHFS2021" was defined multiple times with different content (see the help page).

[3] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 452. ISBN 9783527607495. Archived from the original on 2021-01-22. Retrieved 2021-03-03.

[WHO23rd-4] World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.

[GX2021-5] "Calcipotriene Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 25 October 2016. Retrieved 29 December 2021.

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