Clinical data | |
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Trade names | Vantin, others |
Other names | Cephpodoxime, cefpodoxime proxetil |
AHFS/Drugs.com | Monograph |
MedlinePlus | a698024 |
Pregnancy category |
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Routes of administration | By mouth |
Drug class | Antibiotic (3rd generation cephalosporin)[1] |
Legal status | |
Legal status |
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Pharmacokinetic data | |
Bioavailability | 50% |
Protein binding | 21% to 29% |
Metabolism | Negligible. Cefpodoxime proxetil is metabolized to cefpodoxime by the liver |
Elimination half-life | 2 hours |
Excretion | Kidney, unchanged |
Identifiers | |
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Chemical and physical data | |
Formula | C15H17N5O6S2 |
Molar mass | 427.45 g·mol−1 |
3D model (JSmol) | |
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Cefpodoxime, sold under the brand name Vantin among others, is an antibiotic used to treat middle ear infections, strep throat, sinusitis, urinary tract infections, and gonorrhea.[2] It is taken by mouth.[2]
Common side effects include diarrhea, nausea, vaginal yeast infections, abdominal pain, and headache.[3] Other side effects may include allergic reactions and Clostridioides difficile infection.[2] While there is no evidence of harm with use in pregnancy, such use has not been well studied.[4] It is a third-generation cephalosporin and works by interfering with the bacterial cell wall.[1]
Cefpodoxime was patented in 1980 and approved for medical use in 1989.[5] It is available as a generic medication.[2] In the United States 20 tablets of 200 mg costs about 36 USD as of 2021.[6]
References
edit- ^ a b Beauduy, Camille E.; Winston, Lisa G. (2020). "43. Beta-lactam and other cell wall - & membrane - active antibiotics". In Katzung, Bertram G.; Trevor, Anthony J. (eds.). Basic and Clinical Pharmacology (15th ed.). New York: McGraw-Hill. p. 832. ISBN 978-1-260-45231-0. Archived from the original on 2021-10-10. Retrieved 2021-11-30.
- ^ a b c d e "Cefpodoxime Monograph for Professionals". Drugs.com. Archived from the original on 28 January 2021. Retrieved 30 December 2021.
- ^ a b "DailyMed - CEFPODOXIME PROXETIL tablet, film coated". dailymed.nlm.nih.gov. Archived from the original on 28 December 2021. Retrieved 30 December 2021.
- ^ "Cefpodoxime (Vantin) Use During Pregnancy". Drugs.com. Archived from the original on 29 November 2020. Retrieved 30 December 2021.
- ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 495. ISBN 9783527607495. Archived from the original on 2016-12-20. Retrieved 2021-06-11.
- ^ "Cefpodoxime Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 9 November 2016. Retrieved 30 December 2021.