Clinical data | |
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Trade names | Loprox, Penlac, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a604021 |
Pregnancy category |
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Routes of administration | Topical (applied as a nail lacquer, skin cream or shampoo) |
Drug class | Antifungal[1] |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | <5% with prolonged use |
Protein binding | 94 to 97% |
Elimination half-life | 1.7 hours |
Identifiers | |
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Chemical and physical data | |
Formula | C12H17NO2 |
Molar mass | 207.269 g·mol−1 |
3D model (JSmol) | |
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Ciclopirox (CPX) is an antifungal used to treat ringworm, tinea versicolor, candidiasis of the skin, seborrheic dermatitis, and fungal infection of the nail.[1] It is applied as a gel, cream, or nail polish.[2] Use on toenails is only recommended when less than 40% of the nail is involved.[3]
It is generally well tolerated.[2] Common side effects include mild redness and burning.[1] Other side effects may include allergic reactions.[2] While there is no evidence of harm in pregnancy, such use has not been well studied.[4] Its mechanism of action differs from other antifungals.[2]
Ciclopirox was approved for medical use in the United States in 1982.[1] It is available as a generic medication.[5] In the United States a bottle of 6.6 ml of the nail polish costs about 16 USD as of 2022.[5]
References
edit- ^ a b c d e f "Ciclopirox Monograph for Professionals". Drugs.com. Archived from the original on 25 January 2021. Retrieved 4 January 2022.
- ^ a b c d Gupta, Aditya K.; Mays, Rachel R.; Folley, Kelly A. (2019). "42. Topical antifungal agents". In Wolverton, Stephen E.; Wu, Jashin J. (eds.). Comprehensive Dermatologic Drug Therapy (4th ed.). Elsevier. p. 487. ISBN 978-0-323-61211-1. Archived from the original on 2021-10-09. Retrieved 2021-10-07.
- ^ Ton, Joey (3 September 2019). "#242 Putting the FUN in Fungi: Toenail onychomycosis treatments". CFPCLearn. Archived from the original on 28 March 2023. Retrieved 15 June 2023.
- ^ "Ciclopirox topical Use During Pregnancy". Drugs.com. Archived from the original on 21 October 2020. Retrieved 4 January 2022.
- ^ a b "Ciclopirox Prices and Ciclopirox Coupons - GoodRx". GoodRx. Archived from the original on 1 November 2016. Retrieved 4 January 2022.