User:Mr. Ibrahem/Plecanatide

Mr. Ibrahem/Plecanatide
Clinical data
Trade names	Trulance
Other names	SP-304
AHFS/Drugs.com	Monograph
License data	US FDA: Plecanatide;
Routes of; administration	By mouth
Drug class	Guanylate cyclase C agonist
Legal status
Legal status	US: ℞-only;
Chemical and physical data
Formula	C65H104N18O26S4
Molar mass	1681.89 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1C(=O)NC2CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(NC(=O)CNC(=O)C(NC2=O)C(C)O)C(=O)NC(CC(C)C)C(=O)O)C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)C(C)C)CC(=O)N)C(C)C)CC(C)C)CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(CC(=O)N)N;
	InChI InChI=1S/C65H104N18O26S4/c1-25(2)15-34-55(98)80-41-24-113-110-21-38(58(101)77-37(65(108)109)16-26(3)4)71-44(87)20-69-62(105)50(30(10)84)83-61(104)40(78-51(94)29(9)70-63(106)48(27(5)6)81-57(100)35(18-43(68)86)76-64(107)49(28(7)8)82-60(41)103)23-112-111-22-39(59(102)73-32(53(96)75-34)11-13-45(88)89)79-54(97)33(12-14-46(90)91)72-56(99)36(19-47(92)93)74-52(95)31(66)17-42(67)85/h25-41,48-50,84H,11-24,66H2,1-10H3,(H2,67,85)(H2,68,86)(H,69,105)(H,70,106)(H,71,87)(H,72,99)(H,73,102)(H,74,95)(H,75,96)(H,76,107)(H,77,101)(H,78,94)(H,79,97)(H,80,98)(H,81,100)(H,82,103)(H,83,104)(H,88,89)(H,90,91)(H,92,93)(H,108,109)/t29-,30+,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,48-,49-,50-/m0/s1 ; Key:NSPHQWLKCGGCQR-DLJDZFDSSA-N ;

Plecanatide, sold under the brand name Trulance, is a medication used to treat chronic idiopathic constipation (CIC) and constipation due to irritable bowel syndrome.^[1] It is taken by mouth.^[1]

Common side effects include diarrhea.^[1] Use is not recommended in children.^[2] Safety in pregnancy is unclear.^[3] It works by activating guanylate cyclase-C which increases release of chloride and bicarbonate into the intestines.^[2]

Plecanatide was approved for medical use in the United States in 2017.^[1] In the United States it costs about 470 USD per month.^[4]

References

^ ^a ^b ^c ^d ^e ^f ^g ^h "DailyMed - TRULANCE IMMEDIATE RELEASE- plecanatide tablet". dailymed.nlm.nih.gov. Archived from the original on 28 March 2021. Retrieved 28 October 2021.
^ ^a ^b "Plecanatide Monograph for Professionals". Drugs.com. Archived from the original on 5 March 2019. Retrieved 28 October 2021.
^ "Plecanatide (Trulance) Use During Pregnancy". Drugs.com. Archived from the original on 28 October 2020. Retrieved 28 October 2021.
^ "Plecanatide Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 28 October 2021.

[PI2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h "DailyMed - TRULANCE IMMEDIATE RELEASE- plecanatide tablet". dailymed.nlm.nih.gov. Archived from the original on 28 March 2021. Retrieved 28 October 2021.

[AHFS2021-2] "Plecanatide Monograph for Professionals". Drugs.com. Archived from the original on 5 March 2019. Retrieved 28 October 2021.

[3] "Plecanatide (Trulance) Use During Pregnancy". Drugs.com. Archived from the original on 28 October 2020. Retrieved 28 October 2021.

[4] "Plecanatide Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 28 October 2021.

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