 | |
| Clinical data | |
|---|---|
| Trade names | Elitek, Fasturtec |
| AHFS/Drugs.com | Monograph |
| License data |
|
| Pregnancy category |
|
| Routes of administration | Intravenous infusion |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Bioavailability | N/A |
| Elimination half-life | 18 hrs |
| Identifiers | |
| |
| Chemical and physical data | |
| Formula | C1521H2381N417O461S7 |
| Molar mass | 34109.66 g·mol−1 |
  (what is this?) (verify) | |
Rasburicase, sold under the brand names Elitek among others, is a medication used for high uric acid levels that occur as a result of tumor lysis syndrome.[1] It is given by gradual injection into a vein.[1]
Common side effects include nausea, fever, swelling, anxiety, headache, diarrhea, and low phosphate.[1] Other side effects may include anaphylaxis and methemoglobinemia.[3] It should not be used in people with G6PD deficiency.[3] It is the urate oxidase enzyme created by recombinant DNA technology.[3]
Rasburicase was approved for medical use in Europe in 2001 and the United States in 2002.[1][4] It is on the World Health Organization's List of Essential Medicines.[5] In the United Kingdom it costs the NHS about £350 per 7.5mg vial as of 2021.[2] This amount in the United States costs about 5,000 USD.[6]
References
edit- ^ a b c d e f "DailyMed - ELITEK- rasburicase kit". dailymed.nlm.nih.gov. Archived from the original on 20 March 2021. Retrieved 16 October 2021.
- ^ a b BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 994. ISBN 978-0-85711-369-6.
{{cite book}}: CS1 maint: date format (link) - ^ a b c "Rasburicase Monograph for Professionals". Drugs.com. Archived from the original on 5 August 2019. Retrieved 16 October 2021.
- ^ "Fasturtec". Archived from the original on 28 December 2020. Retrieved 16 October 2021.
- ^ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
- ^ "Elitek Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 20 January 2021. Retrieved 16 October 2021.