Clinical data | |
---|---|
Trade names | Kenalog, Nasacort, others |
Other names |
(8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one; (1R,2S,10S,11S,13R,14S,15S,17S)-1-fluoro-13,14,17-trihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one |
AHFS/Drugs.com | Topical: Monograph Systemic: Monograph ENT: Monograph |
MedlinePlus | a601122 |
License data | |
Pregnancy category |
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Routes of administration | By mouth, topical, IM, intra-articular, intrasynovial |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Protein binding | 68% |
Metabolism | Liver |
Elimination half-life | 88 minutes |
Excretion | Fecal and Kidney |
Identifiers | |
| |
Chemical and physical data | |
Formula | C21H27FO6 |
Molar mass | 394.439 g·mol−1 |
3D model (JSmol) | |
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(what is this?) (verify) |
Triamcinolone is a glucocorticoid used to treat certain skin diseases, allergies, and rheumatic disorders among others.[2] It is also used to prevent worsening of asthma and COPD.[2] It can be taken in various ways including by mouth, injection into a muscle, and inhalation.[2]
Common side effects with long term use include osteoporosis, cataracts, thrush, and muscle weakness.[2] Serious side effects may include psychosis, increased risk of infections, adrenal suppression, and bronchospasm.[2] Use in pregnancy is generally safe.[4] It works by decreasing inflammation and immune system activity.[2]
Triamcinolone was patented in 1956 and came into medical use in 1958.[5] It is on the World Health Organization's List of Essential Medicines as an alternative for triamcinolone hexacetonide.[6] It is available as a generic medication.[7] In the United States the wholesale cost is about US$0.06 per gram for the cream.[8] In 2017, it was the 103rd most commonly prescribed medication in the United States, with more than seven million prescriptions.[9][10]
References
edit- ^ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 1172. ISBN 9780857113382.
- ^ a b c d e f g "Triamcinolone Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 7 August 2019. Retrieved 3 March 2019.
{{cite web}}
: More than one of|archivedate=
and|archive-date=
specified (help); More than one of|archiveurl=
and|archive-url=
specified (help) - ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 1 July 2020. Retrieved 5 September 2020.
{{cite web}}
: More than one of|archivedate=
and|archive-date=
specified (help); More than one of|archiveurl=
and|archive-url=
specified (help) - ^ "Triamcinolone Use During Pregnancy". Drugs.com. Archived from the original on 24 January 2021. Retrieved 3 March 2019.
{{cite web}}
: More than one of|archivedate=
and|archive-date=
specified (help); More than one of|archiveurl=
and|archive-url=
specified (help) - ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 486. ISBN 978-3-527-60749-5. Archived from the original on 2016-12-22. Retrieved 2019-03-01.
{{cite book}}
: More than one of|accessdate=
and|access-date=
specified (help); More than one of|archivedate=
and|archive-date=
specified (help); More than one of|archiveurl=
and|archive-url=
specified (help) - ^ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
- ^ Vallerand, April Hazard (2018). Davis's Drug Guide for Nurses. F.A. Davis. p. 365. ISBN 978-0-8036-7000-6. Archived from the original on 2021-08-29. Retrieved 2019-03-09.
{{cite book}}
: More than one of|accessdate=
and|access-date=
specified (help); More than one of|archivedate=
and|archive-date=
specified (help); More than one of|archiveurl=
and|archive-url=
specified (help) - ^ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-06. Retrieved 3 March 2019.
{{cite web}}
: More than one of|archivedate=
and|archive-date=
specified (help); More than one of|archiveurl=
and|archive-url=
specified (help) - ^ "The Top 300 of 2020". ClinCalc. Archived from the original on 18 March 2020. Retrieved 11 April 2020.
{{cite web}}
: More than one of|archivedate=
and|archive-date=
specified (help); More than one of|archiveurl=
and|archive-url=
specified (help) - ^ "Triamcinolone - Drug Usage Statistics". ClinCalc. Archived from the original on 12 April 2020. Retrieved 11 April 2020.
{{cite web}}
: More than one of|archivedate=
and|archive-date=
specified (help); More than one of|archiveurl=
and|archive-url=
specified (help)