User:Mr. Ibrahem/Triptorelin

Mr. Ibrahem/Triptorelin
Clinical data
Trade names	Decapeptyl, Gonapeptyl, Triptodur, others
AHFS/Drugs.com	Monograph
Pregnancy; category	X;
Routes of; administration	IM
Drug class	GnRH analogue; GnRH agonist; antigonadotropin
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Excretion	Kidney
Identifiers
	IUPAC name 5-oxo-D-prolyl-L-histidyl-Ltryptophyl-L-seryl-Ltyrosyl-3-(1H-indol-2-yl)-L-alanylleucyl-L-arginyl-L-prolylglycinamide;
Chemical and physical data
Formula	C64H82N18O13
Molar mass	1311.473 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C)C[C@@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N)NC(=O)[C@@H](Cc2c[nH]c3c2cccc3)NC(=O)[C@H](Cc4ccc(cc4)O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc5c[nH]c6c5cccc6)NC(=O)[C@H](Cc7cnc[nH]7)NC(=O)[C@@H]8CCC(=O)N8;
	InChI InChI=1S/C64H82N18O13/c1-34(2)23-46(56(88)75-45(13-7-21-69-64(66)67)63(95)82-22-8-14-52(82)62(94)72-31-53(65)85)76-58(90)48(25-36-28-70-42-11-5-3-9-40(36)42)78-57(89)47(24-35-15-17-39(84)18-16-35)77-61(93)51(32-83)81-59(91)49(26-37-29-71-43-12-6-4-10-41(37)43)79-60(92)50(27-38-30-68-33-73-38)80-55(87)44-19-20-54(86)74-44/h3-6,9-12,15-18,28-30,33-34,44-52,70-71,83-84H,7-8,13-14,19-27,31-32H2,1-2H3,(H2,65,85)(H,68,73)(H,72,94)(H,74,86)(H,75,88)(H,76,90)(H,77,93)(H,78,89)(H,79,92)(H,80,87)(H,81,91)(H4,66,67,69)/t44-,45-,46-,47-,48+,49-,50-,51-,52-/m0/s1 ; Key:VXKHXGOKWPXYNA-PGBVPBMZSA-N ;
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Triptorelin, sold under the brand names Decapeptyl among others, is a medication used for endometriosis, fibroids, prostatic cancer, precocious puberty, and to male hypersexuality with severe sexual deviation.^[1]^[2] It has also been used to delay puberty in people with gender dysphoria.^[3] It is given by injection into a muscle.^[1]

Common side effects include flushing, sexual dysfunction, pain at the site of injection, and high blood sugar.^[1] Other side effects may include pituitary apoplexy, irritability, blood clots, and anaphylaxis.^[1] Use during pregnancy may harm the baby.^[1] It is a gonadotropin-releasing hormone which decreases the production of androgens and estrogen.^[2]

Triptorelin was patented in 1975 and approved for medical use in 1986.^[4] It is on the World Health Organization's List of Essential Medicines as an alternative to leuprorelin.^[5] In the United Kingdom a 3.75 mg dose costs the NHS about £82 as of 2021.^[2] This amount in the United States costs about 860 USD.^[6]

References

^ ^a ^b ^c ^d ^e ^f ^g "Triptorelin Monograph for Professionals". Drugs.com. Archived from the original on 27 January 2021. Retrieved 20 September 2021.
^ ^a ^b ^c ^d BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 781. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
^ Barnes, Hannah; Cohen, Deborah (2019-09-20). "Gender dysphoria in children: puberty blockers study draws further criticism". BMJ. 366: l5647. doi:10.1136/bmj.l5647. ISSN 0959-8138. PMID 31540909. S2CID 202711942. Archived from the original on 2021-06-16. Retrieved 2021-07-14.
^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 514. ISBN 9783527607495. Archived from the original on 2021-06-20. Retrieved 2021-07-14.
^ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
^ "Trelstar Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 19 April 2021. Retrieved 20 September 2021.